Graphene quantum dots-polyfluorene hybrid nanobiosensor for mitomycin C-DNA interaction sensing

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dc.authorid0000-0001-9432-8338
dc.authorid0000-0003-0493-8154
dc.authorid0000-0001-9376-1770
dc.contributor.authorEmre, Deniz
dc.contributor.authorDenizhan, Nuray
dc.contributor.authorÖzkan Arıksoysal, Dilşat
dc.contributor.authorBilici, Ali
dc.contributor.authorSonkaya, Ömer
dc.contributor.authorAlgı, Fatih
dc.contributor.authorAlgı, Fatih
dc.contributor.authorYılmaz, Selehattin
dc.date.accessioned2024-05-03T13:16:05Z
dc.date.available2024-05-03T13:16:05Z
dc.date.issued2024
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractA novel graphene quantum dots (GQD) / polyfluorene (PF) nanocomposite was deposited on the disposable pencil tip graphite electrode (PGE) and proven to be an efficient nanosensor for analysis of the electrochemical interaction between the antitumor compound mitomycin C (MC) with double stranded DNA (ds-DNA). This modified electrode (GQD@PF-PGE) was prepared in four steps: hydrothermal, chemical oxidation, ultra-sonication and electro-oxidation processes. GQD, PF, GQD@PF and GQD@PF-PGE have been characterized by different analytical techniques such as SEM, TEM, XRD, FTIR, UV-Vis, EIS. Compared to bare PGE, GQD@PF modified PGE performed approximately 56 times more sensitive analysis when evaluating the guanine oxidation signals measured by DPV. CV and EIS measurements also showed that GQD@PF-PGE possesses a fast electron transfer as compared to bare electrode and exhibit a remarkable electrocatalytic activity towards both guanine and MC electrooxidation. Comprehensive optimization studies have also been carried out for the developed new nanobiosensor.
dc.identifier.doi10.1016/j.mseb.2023.116944
dc.identifier.issn0921-5107
dc.identifier.issn1873-4944
dc.identifier.scopusqualityQ1
dc.identifier.urihttps:/dx.doi.org10.1016/j.mseb.2023.116944
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11773
dc.identifier.volume299en_US
dc.identifier.wosWOS:001097132500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMaterials Science and Engineering: B
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectGraphene Quantum Dots
dc.subjectElectrochemical DNA Biosensor
dc.subjectPolyfluorene
dc.subjectElectropolymerization
dc.subjectMitomycin C
dc.subjectPencil Graphite Electrode
dc.titleGraphene quantum dots-polyfluorene hybrid nanobiosensor for mitomycin C-DNA interaction sensing
dc.typeArticle

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