The biochemical effects of dietary chromium in experimental diabetic rats with streptozotocin

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dc.contributor.authorBüyükleblebici, Olga
dc.contributor.authorKaragül, Hilal
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:30Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:30Z
dc.date.issued2012
dc.departmentVeteriner Fakültesi
dc.description.abstractChromium is the main dietary supplement for mammals which has important functions at carbohydrate, lipid and protein metabolisms. Chromium picolinate (Cr(pic)3) may improve insulin sensivity by enhancing intracelluler insulin receptor. In this study we investigated the effects of chromium picolinate at experimental diabetic rats with streptozotocin (STZ). With this purpose serum glucose, insuline, paraoxonase, lipid and HbA1C levels were examined. Thirty male Wistar Albino rats were used which divided into 4 groups. Diabet and diabet+chromium groups were injected STZ intraperitoneally (65 mg/kg). After diabet is formed, Cr(pic) 3 was added to drinking water of diabet and diabet+chromium groups (80 mu g/kg) for five weeks.. Control and chromium groups had lower serum HbA1C levels than the other groups (P < 0.001), but diabet+chromium had lower results than diabet group. Serum paraoxonase levels of diabet group were also lower than the other groups (P < 0.01). It means that the activity of paraoxonase is still high in diabet+chromium group in spite of diabet. Insulin levels of diabetic+chromium group were higher than diabetic group which means that chromium may have an effect that increases stimulation of insulin on beta cells. As conclusion, chromium is the most searched leading element related with insulin and stimulates insulin receptors or enhances the secretion. In suggestion, it can be supplemented on the diets of diabetic patients.
dc.identifier.endpage26en_US
dc.identifier.issn1300-6045
dc.identifier.issue1en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6048
dc.identifier.volume18en_US
dc.identifier.wosWOS:000302228400004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotr
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISI
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes Mellitus
dc.subjectChromium Picolinate
dc.subjectParaoxonase
dc.subjectLipid Profile
dc.titleThe biochemical effects of dietary chromium in experimental diabetic rats with streptozotocin
dc.typeArticle

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