The biochemical effects of dietary chromium in experimental diabetic rats with streptozotocin
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Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
KAFKAS UNIV, VETERINER FAKULTESI DERGISI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Chromium is the main dietary supplement for mammals which has important functions at carbohydrate, lipid and protein metabolisms. Chromium picolinate (Cr(pic)3) may improve insulin sensivity by enhancing intracelluler insulin receptor. In this study we investigated the effects of chromium picolinate at experimental diabetic rats with streptozotocin (STZ). With this purpose serum glucose, insuline, paraoxonase, lipid and HbA1C levels were examined. Thirty male Wistar Albino rats were used which divided into 4 groups. Diabet and diabet+chromium groups were injected STZ intraperitoneally (65 mg/kg). After diabet is formed, Cr(pic) 3 was added to drinking water of diabet and diabet+chromium groups (80 mu g/kg) for five weeks.. Control and chromium groups had lower serum HbA1C levels than the other groups (P < 0.001), but diabet+chromium had lower results than diabet group. Serum paraoxonase levels of diabet group were also lower than the other groups (P < 0.01). It means that the activity of paraoxonase is still high in diabet+chromium group in spite of diabet. Insulin levels of diabetic+chromium group were higher than diabetic group which means that chromium may have an effect that increases stimulation of insulin on beta cells. As conclusion, chromium is the most searched leading element related with insulin and stimulates insulin receptors or enhances the secretion. In suggestion, it can be supplemented on the diets of diabetic patients.
Açıklama
Anahtar Kelimeler
Diabetes Mellitus, Chromium Picolinate, Paraoxonase, Lipid Profile
Kaynak
KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
18
Sayı
1
