Comparison of serum paraoxonase 1 (PON1) activities among different sheep breeds in Turkey

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dc.contributor.authorArslan, Mikail
dc.contributor.authorErzengin, Mahmut
dc.contributor.authorDemir, Dudu
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:23:47Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:23:47Z
dc.date.issued2011
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractParaoxonase 1 (PON1, EC 3.1.8.1) is a calcium dependent mammalian enzyme that is synthesized primarily in the liver and is secreted into the serum where it is associated with High Density Lipoproteins (HDLs) and has a protective effect against oxidation of Low Density Lipoproteins (HDLs). Beside antioxidant and antiatherogenic properties, PON1 is also a detoxifier that can hydrolyze toxic organophosphates. Several studies have shown that PON1 can bind reversibly to organophosphate substrates which it hydrolyzes. Therefore, PON1 is the main means of protection of the nervous system against the neurotoxicity of organophosphates entering the circulation. This study was conducted to characterization of serum Paraoxonase 1 (PON1) activity from different sheep breeds namely Karacabey Merino, Kivircik, Tahirova, Akkaraman and Daglic. KM and Vmax values of five different sheep breed were determined by Lineweaver-Burk method. The values of Vmax/KM showed that Kivircik breed has the greatest PON1 activity, on the other hand, Karacabey Merino breed showed the least activity toward paraoxon substrate. © Medwell Journals, 2011.
dc.identifier.doi10.3923/javaa.2011.489.494
dc.identifier.endpage494en_US
dc.identifier.issn1680-5593
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage489en_US
dc.identifier.urihttps://dx.doi.org/10.3923/javaa.2011.489.494
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2819
dc.identifier.volume10en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of Animal and Veterinary Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAkkaraman
dc.subjectDaglic
dc.subjectKaracabey Merino
dc.subjectKivircik
dc.subjectSheep Paraoxonase 1
dc.subjectTahirova
dc.titleComparison of serum paraoxonase 1 (PON1) activities among different sheep breeds in Turkey
dc.typeArticle

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