Protective effects of quercetin against vincristine-ınduced nephrotoxicity via modulation of oxidative stress, ınflammation, and apoptosis in rats

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dc.authorid0000-0002-8222-5515
dc.contributor.authorKandemir, Özge
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorÖzdemir, Selçuk
dc.contributor.authorDalkılıç, Elif
dc.contributor.authorSağ, Sevda
dc.contributor.authorÇağlayan, Cüneyt
dc.contributor.authorKandemir, Fatih Mehmet
dc.date.accessioned2025-09-25T05:26:19Z
dc.date.available2025-09-25T05:26:19Z
dc.date.issued2025
dc.departmentTeknik Bilimler Meslek Yüksekokulu
dc.description.abstractVincristine is a widely used chemotherapeutic agent in pediatric leukemias and solid tumors, but the use of this chemotherapeutic agent is associated with many organ damages, especially nephrotoxicity. Quercetin, a natural flavonoid, is known for its antioxidant and anti-inflammatory potential. Vincristine was intraperitoneally administered at a dose of 0.1 mg/kg body weight, and quercetin was orally administered at doses of 25 and 50 mg/kg body weight. Both treatments were applied to the rats on days 1–6 and 9–14. Renal function was assessed via serum urea and creatinine levels. Oxidative stress and lipid peroxidation were evaluated by measuring GSH, SOD, CAT, GPx, and MDA. The mRNA levels of apoptotic markers such as p53, Bax, Bcl-2, Jnk and Beclin-1 and inflammatory markers such as TNF-α, IL-1β, COX-2, and PGE-2 were analyzed by RT-qPCR. The HO-1, Nrf2, PGC-1α and SIRT1, NFκB and STAT3 protein levels were determined by ELISA. In addition, the protein levels of PI3K and AKT in survival pathways were analyzed using the Western blot method. The results showed that vincristine significantly impaired renal function by increasing oxidative stress, inflammation, and apoptosis. Quercetin protected renal function by enhancing antioxidant defense, reducing inflammatory signals and reversing apoptosis. The findings reveal that quercetin exhibits protective effects against vincristine-induced nephrotoxicity through antioxidant, anti-inflammatory and antiapoptotic mechanisms.
dc.identifier.doi10.1002/jbt.70516
dc.identifier.issn10956670
dc.identifier.issue9
dc.identifier.pmid40936432
dc.identifier.scopus2-s2.0-105015694435
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.70516
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14541
dc.identifier.volume39
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.institutionauthorKandemir, Özge
dc.institutionauthorKandemir, Fatih Mehmet
dc.institutionauthorid0000-0001-8884-4168
dc.institutionauthoridhttps://orcid.org/0000-0002-8490-2479
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectAutophagy
dc.subjectOxidative Stress
dc.subjectQuercetin
dc.subjectVincristine
dc.subjectNephrotoxicity
dc.titleProtective effects of quercetin against vincristine-ınduced nephrotoxicity via modulation of oxidative stress, ınflammation, and apoptosis in rats
dc.typeArticle

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