Potential impact of obstetric history on postmenopausal fragility fracture risk: A reassessment of the Fracture Risk Assessment Tool

Sezgin, Aydan; Saçıntı, Huriye Güvenç; Osmanlı, Elşad; Mangır, Kübra; Saçıntı, Koray Görkem; Sezgin, Erdem Aras

Potential impact of obstetric history on postmenopausal fragility fracture risk: A reassessment of the Fracture Risk Assessment Tool

dc.authorid	0000-0002-3711-5747
dc.authorid	0000-0003-1886-7529
dc.authorid	0000-0002-6621-383X
dc.authorid	0000-0002-2009-7597
dc.authorid	0000-0002-8602-9714
dc.authorid	0000-0001-5869-6571
dc.contributor.author	Sezgin, Aydan
dc.contributor.author	Saçıntı, Huriye Güvenç
dc.contributor.author	Osmanlı, Elşad
dc.contributor.author	Mangır, Kübra
dc.contributor.author	Saçıntı, Koray Görkem
dc.contributor.author	Sezgin, Erdem Aras
dc.date.accessioned	2025-04-16T08:49:03Z
dc.date.available	2025-04-16T08:49:03Z
dc.date.issued	2024
dc.department	Tıp Fakültesi
dc.description.abstract	Objectives: This study aimed to evaluate the impact of integrating obstetric parameters into the Fracture Risk Assessment Tool (FRAX) on the precision of risk assessment. Patients and methods: In this retrospective study, patients who experienced postmenopausal fragility fractures of the distal radius, proximal femur, or lumbar vertebrae between January 1, 2021, and December 31, 2023, were included. Obstetric histories, along with standard FRAX parameters, were obtained by phone interviews. Based on the FRAX major osteoporotic fracture risk score calculated without bone mineral density, patients were classified into high-, intermediate-, and low-risk group categories. Differences in age at menarche, age at menopause, lactation duration, gravidity, and parity were analyzed across risk categories. Results: A total of 328 patients (mean age: 64.5±5.8 years; range, 55 to 75 years) were included. The mean FRAX score was 16±8.8 (range, 3 to 58), and 85, 191, and 52 patients were classified as high-, intermediate-, and low-risk, respectively. A positive correlation was observed between FRAX scores and both later age at menarche and earlier menopause (p<0.001 and p=0.008, respectively). The mean age at menopause was significantly different between the high- and low-risk groups (46.4 vs. 49.3 years, p=0.016). The intermediate-risk group was also evaluated, showing no significant differences in obstetric parameters compared to the low-risk group (p>0.05). Conclusion: Although late menarche is not explicitly included in FRAX, its association with higher fracture risk was evident. The established influence of early menopause on FRAX scores supports its role in fracture risk estimation. However, the inclusion of additional obstetric parameters did not enhance the predictive accuracy of FRAX in this cohort.
dc.identifier.doi	10.52312/jdrs.2025.1995
dc.identifier.endpage	147
dc.identifier.issn	26874792
dc.identifier.issue	1
dc.identifier.scopus	2-s2.0-85213928506&
dc.identifier.scopusquality	Q2
dc.identifier.startpage	142
dc.identifier.uri	https://dx.doi.org/10.52312/jdrs.2025.1995
dc.identifier.uri	https://hdl.handle.net/20.500.12451/13062
dc.identifier.volume	36
dc.identifier.wos	001375819400001
dc.identifier.wosquality	Q2
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.institutionauthor	Saçıntı, Koray Görkem
dc.institutionauthor	Sezgin, Erdem Aras
dc.institutionauthorid	0000-0002-8602-9714
dc.institutionauthorid	0000-0001-5869-6571
dc.language.iso	en
dc.publisher	Turkish Joint Diseases Foundation
dc.relation.ispartof	Joint Diseases and Related Surgery
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	Menarche
dc.subject	Osteoporosis
dc.subject	Osteoporotic Fractures
dc.subject	Postmenopausal
dc.subject	Risk Assessment
dc.title	Potential impact of obstetric history on postmenopausal fragility fracture risk: A reassessment of the Fracture Risk Assessment Tool
dc.type	Article