Effect of riluzole on spinal cord regeneration with hemisection method before injury

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dc.contributor.authorÇağlar, Yusuf Şükrü
dc.contributor.authorDemirel, Altan
dc.contributor.authorDoğan, İhsan
dc.contributor.authorHüseynov, Ramis
dc.contributor.authorEroğlu, Ümit
dc.contributor.authorÖzgüral, Onur
dc.contributor.authorCansız, Cevriye
dc.contributor.authorBahadır, Burak
dc.contributor.authorKılınç, Mustafa Cemil
dc.contributor.authorAl-Beyati, Eyyüb S.M.
dc.date.accessioned2025-10-09T07:56:38Z
dc.date.available2025-10-09T07:56:38Z
dc.date.issued2018
dc.departmentTıp Fakültesi
dc.description.abstractThe pathophysiology of spinal cord injury (SCI) with the information obtained to date has not been elucidated fully. A safe drug or treatment protocol that results in cell regeneration for SCI remains unknown. Neuroprotective and neuroregenerative effects of riluzole, administered after a SCI, have been shown in experimental studies. This study aimed to investigate the effect of riluzole on neural regeneration in a rat SCI model. Methods: Thirty-two rats were divided into 8 groups, with 4 rats in each group. Hemisection method was performed after T7–T9 laminectomy. Rats were intraperitoneally aministered with riluzole (6 mg/kg). Locomotor recovery of the rats was assessed at 1 day, and 1, 2, 3, and 4 weeks after the 21-point Basso, Beattie, and Bresnahan test. Subsequently, the spinal cords of the rats were scored according to a semiquantitative grading system using a light microscope, and the numbers of myelinated axons, neurons, and glial cells were calculated. Results: Basso, Beattie, and Bresnahan test changes were statistically significant when groups 4–6 and 8 were compared with the other groups (P < 0.05, P < 0.00625). The results of the numbers of neurons, glial cells, and myelinated axons were statistically significant. Especially group 8, in which riluzole was administered 5 days before injury, more positive clinical and histopathologic results were obtained. Conclusions: Riluzole treatment is more effective when provided before injury. Riluzole may contribute to functional recovery when used in the preoperative period in patients who are at a high risk for permanent neurologic deficit.
dc.identifier.doi10.1016/j.wneu.2018.02.171
dc.identifier.endpagee253
dc.identifier.issn18788750
dc.identifier.pmid29530700
dc.identifier.scopus2-s2.0-85045922632
dc.identifier.scopusqualityQ3
dc.identifier.startpagee247
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2018.02.171
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14612
dc.identifier.volume114
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemirel, Altan
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofWorld Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeuroprotection
dc.subjectNeuroregeneration
dc.subjectRiluzole
dc.subjectSpinal Cord Injury
dc.titleEffect of riluzole on spinal cord regeneration with hemisection method before injury
dc.typeArticle

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