Synthesis, characterization, and pharmacological evaluation of the proton transfer salts of 2-aminobenzothiazole derivatives with 5-sulfosalicylic acid and their Cu(II) complexes

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dc.contributor.authorİlkimen, Halil
dc.contributor.authorTeksen, Yasemin
dc.contributor.authorYenikaya, Cengiz
dc.contributor.authorTurhan, Irem
dc.contributor.authorTunç, Tuncay
dc.contributor.authorSarı, Musa
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:17:28Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:17:28Z
dc.date.issued2018
dc.departmentEğitim Fakültesi
dc.description.abstractTwo proton transfer compounds, formed between 2-aminobenzothiazole derivatives (2-aminobenzothiazole (abt) and 2-amino-6-ethoxybenzothiazole (EtOabt)) and 5-sulfosalicylic acid dihydrate (H3ssa) as parent compounds, (Habt)(+) (H2ssa)(-) (1) and (HEtOabt)(+) (H2ssa)(-) (2) and their Cu(II) complexes (3 and 4, respectively) have been prepared and characterized using spectroscopic techniques. The single crystal X-ray diffraction method has been also applied to 3 and 4. Although 3 has a distorted octahedral form, 4 exhibits a distorted square pyramidal geometry. All compounds, including saline and diclofenac sodium as standards, have been evaluated pharmacologically for their anti-inflammatory and analgesic activities in rats and mice. Parent compounds (abt, EtOabt, and H3ssa) 3 and 4 showsignificant anti-inflammatory and analgesic activities as compared with control compounds. [GRAPHICS] .
dc.description.sponsorshipDumlupinar University Research Fund [2017/09]
dc.description.sponsorshipThe authors acknowledge the support provided by Dumlupinar University Research Fund (Grant No. 2017/09).
dc.identifier.doi10.1080/00958972.2018.1504035
dc.identifier.endpage2842en_US
dc.identifier.issn0095-8972
dc.identifier.issn1029-0389
dc.identifier.issue16-18en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage2831en_US
dc.identifier.urihttps://doi.org/10.1080/00958972.2018.1504035
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4752
dc.identifier.volume71en_US
dc.identifier.wosWOS:000457548200025
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject2-Aminobenzothiazole Derivatives
dc.subject5-Sulfosalicylic Acid
dc.subjectProton Transfer Salt
dc.subjectAnti-inflammatory Activity
dc.subjectAnalgesic Activity
dc.titleSynthesis, characterization, and pharmacological evaluation of the proton transfer salts of 2-aminobenzothiazole derivatives with 5-sulfosalicylic acid and their Cu(II) complexes
dc.typeArticle

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