Alteration in choroidal microvasculature determined by optical coherence tomography angiography in patients with acromegaly

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dc.contributor.authorSelvinaz, Erol R.
dc.contributor.authorTiryaki, Semra
dc.contributor.authorÇil Şen, Esra
dc.contributor.authorYener, Öztürk F.
dc.contributor.authorMasum, Canat M.
dc.contributor.authorYıldız, Duygu
dc.contributor.authorBatman, Adnan
dc.contributor.authorGüven, Dilek
dc.contributor.authorAltuntaş, Yüksel
dc.contributor.authorSüren, Elçin
dc.contributor.authorKazım, Erol M.
dc.date.accessioned2025-10-10T13:24:23Z
dc.date.available2025-10-10T13:24:23Z
dc.date.issued2021
dc.departmentTıp Fakültesi
dc.description.abstractWe aimed to investigate the retinal layers and macular capillary structure using optical coherence tomography angiography (OCTA) with acromegaly patients and determine the relationship between OCTA parameters and disease duration, Growth hormone (GH) and Insuline growth factor (IGF - 1) levels. Patients and Method: Twenty-two patients with acromegaly who were followed up in the endocrinology outpatient clinic of Sisli Hamidiye Etfal Health Training and Research Hospital, were recruited into the study. Healthy control group was consisted of 22 age and gender matched subjects. Complete opthalmological examination including best visual acuity (BCVA), axial lenght, intraocular pressure (IOP) measurement, anterior segment and fundus examination, central corneal thickness with pachymetry and OCTA measurement were performed in the patients and healthy control group. Foveal avascular zone (FAZ), foveal vascular density (FVD), parafoveal vascular density (PFVD), choroidal flow (CF), foveal thickness (FT) and choroidal thickness (CT) were compared beetwen groups. Correlation between disease duration, GH and IGF-1 levels and OCTA parameters were evaluated. Results: There was no statistically significant difference between the groups in terms of BCVA, axial length, IOP, FT, FAZ, FD and PFVD. Choroidal thickness and CF was significantly high in the patients group compared to healthy controls (respectively, p = 0.003, p = 0.022). The mean follow-up period in patients with acromegaly was 90±50.2 months. There was a significant correlation between GH and subfoveal choroidal thickness in the patient group (p < 0.001, r = 0.52), a significant correlation was determined between disease duration and corneal thickness (p = 0.01, r = 0.41). In addition, an inverse correlation was detected between the IGF-1 level and the FAZ domain (p = 0.022, r= -0.34). Conclusion: In patients with acromegaly, choroidal vasculature seems to be more affected than the retinal vasculature.
dc.identifier.doi10.1016/j.pdpdt.2021.102590
dc.identifier.issn15721000
dc.identifier.scopus2-s2.0-85118489553
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2021.102590
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14694
dc.identifier.volume36
dc.indekslendigikaynakScopus
dc.institutionauthorBatman, Adnan
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofPhotodiagnosis and Photodynamic Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcromegaly
dc.subjectChoroidal Blood Flow
dc.subjectFoveal Avascular Zone
dc.subjectMicsovascularity
dc.subjectOct Angiography
dc.subjectOcta
dc.subjectOptical Coherence Tomography
dc.titleAlteration in choroidal microvasculature determined by optical coherence tomography angiography in patients with acromegaly
dc.typeArticle

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