Characterization of strains induced by in vivo locomotion and axial tibiotarsal loading in a chukar partridge model

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dc.contributor.authorHorasan, Murat
dc.contributor.authorVerner, Kari A.
dc.contributor.authorMain, Russell P.
dc.contributor.authorNauman, Eric A.
dc.date.accessioned2025-07-08T12:09:26Z
dc.date.available2025-07-08T12:09:26Z
dc.date.issued2025
dc.departmentMühendislik Fakültesi
dc.description.abstractRodent models have offered valuable insights into the mechanobiological mechanisms that regulate bone adaptation responses to dynamic mechanical stimuli. However, using avian models may provide new insights into the mechanisms of bone adaptation to dynamic loads, as bird bones have distinct features that differ from mammalian bones. This paper illuminates these aspects by evaluating the mechanical environment in a novel avian, chukar partridge tibiotarsus (TBT), during fast locomotion and in cortical and cancellous tissue under in vivo dynamic compressive loading within the TBT. We measured in vivo mechanical strains at the TBT midshaft on the anterior, medial, and posterior surfaces during locomotion at various treadmill speeds. The mean in vivo strains measured on the anterior, medial, and posterior surfaces of the TBT midshaft were 154 με, -397 με, and -438 με, respectively, at a treadmill speed of 2 m/s. The mean experimentally measured strains on the anterior, medial, and posterior surfaces of the TBT were 114.7 με, -952.6 με, and -593.7 με under an in vivo dynamic compressive load of 130 N. The study, which employs a micro-computed tomography (microCT) based finite element model in combination with diaphyseal strain gauge measures, found that cancellous strains were greater than those in the midshaft cortical bone. Sensitivity analyses revealed that the material property of cortical bone was the most significant model parameter. In the midshaft cortical volume of interest (VOI), daily dynamic loading increased the maximum moment of inertia and reduced the bone area in the loaded limb compared to the contralateral control limb after three weeks of loading. Despite the strong correlations between the computationally modeled strains and experimentally measured strains at the medial and posterior gauge sites, no correlations existed between the computationally modeled strains and strain gradients, and histologically measured bone formation thickness at the mid-diaphyseal cross-section of the TBT.
dc.identifier.doi10.1016/j.bone.2025.117497
dc.identifier.issn87563282
dc.identifier.pmid40280253
dc.identifier.scopus105003153437
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1016/j.bone.2025.117497
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13205
dc.identifier.volume196
dc.identifier.wos001480312400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorHorasan, Murat
dc.language.isoen
dc.publisherElsevier Inc.
dc.relation.ispartofBone
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAvian Model
dc.subjectBone Adaptation
dc.subjectHistology
dc.subjectIn Vivo Loading
dc.subjectLocomotion
dc.subjectMicroCT Finite Element Analysis
dc.subjectTibiotarsus
dc.titleCharacterization of strains induced by in vivo locomotion and axial tibiotarsal loading in a chukar partridge model
dc.typeArticle

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