Effectiveness of Wharton's jelly mesenchymal stem cell medium on burn wound healing: Focus on apoptosis, necrosis, and autophagy

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dc.authorid0000-0002-9667-5728
dc.authorid0000-0003-3118-1054
dc.authorid0000-0003-3118-1054
dc.authorid0000-0002-9334-8721
dc.authorid0000-0001-5905-1062
dc.authorid0000-0003-1585-3359
dc.authorid0000-0002-0364-697X
dc.contributor.authorÇelik Kenar, Zeynep
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorAkçakavak, Gökhan
dc.contributor.authorMajidov, Nijat
dc.contributor.authorÖner, Muhammed
dc.contributor.authorTural Çifçi, Ayşenur
dc.contributor.authorŞahin, Rabia
dc.date.accessioned2025-07-18T13:13:47Z
dc.date.available2025-07-18T13:13:47Z
dc.date.issued2025
dc.departmentVeteriner Fakültesi
dc.description.abstractThe aim of this study is to evaluate the treatment efficacy of Platelet–Rich Plasma (PRP), silver sulfadiazine, and Wharton Jelly Mesenchymal Stem Cell–Derived Conditioned Medium (WJ–MSC– CM) on burn wounds using a rat model. The study included four groups, each with 16 rats, and the groups were further divided into two subgroups (n=8) for the 7th and 14th days of the treatment process. Group 1 received no treatment after the burn. Group 2 received PRP (Platelet–Rich Plasma) treatment on the first day after the burn. Group 3 was treated with silver sulfadiazine on the first day after the burn. Group 4 received WJ–MSC–CM on the first day after the burn. In the current study, the expression of Caspase–3, Bcl–2, TNF–α, p21, and Beclin–1 genes among the groups was evaluated by Real–time PCR. The silver sulfadiazine and WJ–MSC–CM treatment groups exhibited lower Bcl–2 expression and higher Caspase–3 and Beclin–1 expression compared to the other groups. TNF–α and p21 expression was high in the burn control group and showed lower expression in the treated groups. The current findings demonstrate that WJ–MSC–CM exhibits healing efficacy on burn wounds comparable to the reference drug (silver sulfadiazine) by inducing apoptosis and autophagy and reducing necroptosis and DNA damage. Additionally, PRP provided some positive benefits compared to the control group but was less effective than the other treatments.
dc.identifier.doi10.52973/rcfcv-e35517
dc.identifier.issn07982259
dc.identifier.issue1
dc.identifier.scopus105000545141
dc.identifier.urihttps://dx.doi.org/10.52973/rcfcv-e35517
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13392
dc.identifier.volume35
dc.identifier.wosWOS:001439269500020
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAkçakavak, Gökhan
dc.institutionauthorid0000-0003-3118-1054
dc.language.isoen
dc.publisherUniversidad del Zulia, Facultad de Ciencias Veterinarias
dc.relation.ispartofRevista Cientifica de la Facultad de Veterinaria
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectAutophagy
dc.subjectBurn Wounds
dc.subjectWharton Jelly Mesenchymal Stem Cell–derived Conditioned Medium
dc.titleEffectiveness of Wharton's jelly mesenchymal stem cell medium on burn wound healing: Focus on apoptosis, necrosis, and autophagy
dc.title.alternativeEficacia del medio de células madre mesenquimales de la gelatina de Wharton en la cicatrización de quemaduras: Enfoque en apoptosis, necrosis y autofagia
dc.typeArticle

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