Browsing by Author "Tarhan, Mehtap"
Now showing items 1-5 of 5
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Antitumor activities on HL-60 human leukemia cell line, molecular docking, and quantum-chemical calculations of some sulfonamide-benzoxazoles
Öksüzoğlu, Emine; Ertan Bolelli, Tuğba; Can, Hatice; Tarhan, Mehtap; Özturk, Kamile; Yıldız, İlkay (Taylor & Francis Ltd, 2017)We previously synthesized some novel benzoxazole derivatives-containing sulfonamide. In this study, the compounds were investigated for their antitumor activities against the HL-60 human leukemia cells, using the MTT assay. ... -
Antitumor and apoptotic effects of new-generation platinum compounds on human leukemia cell lines HL-60 and K562
Karacaer, Neslihan Tekin; Kerimoğlu, Barış; Baran, Talat; Tarhan, Mehtap; Menteş, Ayfer; Öztürk, Kamile (Springer, 2022)The goal of this investigation is to report the fabrication, characterization, cytotoxicity, and apoptotic assessment of new platinum based compounds on K562 and HL-60 human leukemia cells. Two new platinum (II) compounds, ... -
Cytotoxic and apoptotic activities of novel Pd(II) complexes against human leukemia cell lines in vitro
Tekin, Neslihan; Öztürk, Kamile; Baran, Talat; Kerimoğlu, Barış; Tarhan, Mehtap; Menteş, Ayfer (Taylor & Francis, 2017)In the investigation for alternative chemotherapeutic strategies against leukemia, Pd(II) complexes were synthesized and investigated for cytotoxic and apoptotic properties on two human leukemia cell lines (HL-60 and K562). ... -
Investigation of the possible effect of s-allyl-l-cysteine on apoptosis and autophagy in human leukemia cell line
Tekin Karacaer, Neslihan; Kerimoğlu, Barış; Tarhan, Mehtap; Öztürk, Kamile (Afyonkarahisar Sağlık Bilimleri Üniversitesi, 2021)S-Allyl-L-cysteine (SAC) is a biological active organosulfur component of garlic and has various pharmacological effects. SAC has displayed anti-cancer activity but the mechanism is unresolved. This study has focused on ... -
Multiple Myeloma'da bortezomibe karşı gelişen direnç mekanizmasında toll like reseptörlerin rolünün araştırılması
Tarhan, Mehtap (Aksaray Üniversitesi Fen Bilimleri Enstitüsü, 2017)Multiple myeloma (MM) kemik iliğindeki plazma hücrelerinin anormal proliferasyonu ve invazyonu ile karakterize edilen, tedavi edilemeyen hematolojik bir kanserdir. Günümüzde MM tedavisi için kullanılan en etkin tedavi ...
