Browsing by Author "Kankılıç, Nazım Abdülkadir"
Now showing items 1-4 of 4
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The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death
Kankılıç, Nazım Abdülkadir; Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Gencer, Selman; Kandemir, Fatih Mehmet (Elsevier Ltd, 2024)Bortezomib is a proteasome inhibitor antineoplastic agent that was the first to be approved for cancer treatment. One of bortezomib's most prominent dose-limiting effects is nephrotoxicity; the underlying mechanism is ... -
Investigation of the Effects of Rutin on Valproic Acid Induced Testicular Damage in Rats
Akarsu, Serkan Ali; Kankılıç, Nazım Abdülkadir; Erdoğan, Ender (Afyon Kocatepe Üniversitesi, 2023)Valproic acid (VALP) is a drug used for many psychiatric diseases such as epilepsy. However, the use of VALP has potential side effects on various tissues, including the testicles. Rutin (RUT) is a flavonoid with protective ... -
Naringin protects against paclitaxel-induced toxicity in rat testicular tissues by regulating genes in pro-inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways
Kankılıç, Nazım Abdülkadir; Küçükler, Sefa; Gür, Cihan; Akarsu, Serkan Ali; Akaras, Nurhan; Şimşek, Hasan; İleritürk, Mustafa; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2024)Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and ... -
Protective effects of naringin on colistin-induced damage in rat testicular tissue: Modulating the levels of Nrf-2/HO-1, AKT-2/FOXO1A, Bax/Bcl2/Caspase-3, and Beclin-1/LC3A/LC3B signaling pathways
Kankılıç, Nazım Abdülkadir; Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; İleritürk, Mustafa; Küçükler, Sefa; Akarsu, Serkan A.; Kandemir, Fatih M. (John Wiley and Sons Inc, 2024)Antimicrobial agent resistance has become a growing health issue across the world. Colistin (COL) is one of the drugs used in the treatment of multidrug-resistant bacteria resulting in toxic effects. Naringin (NRG), a ...
