Browsing by Author "Kandemir, Fatih Mehmet"
Now showing items 1-20 of 26
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Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO-1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways
Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier B.V., 2023)Cadmium (Cd) is a toxic heavy metal that targets the kidney directly in the body. Chrysin (CHR) is a natural flavonoid with many properties such as antioxidant, anti-inflammatory and anti-apoptotic. The current study ... -
Beneficial effects of quercetin on vincristine-induced liver injury in rats: Modulating the levels of Nrf2/HO-1, NF-kB/STAT3, and SIRT1/PGC-1α
Çomaklı, Selim; Özdemir, Selçuk; Küçükler, Sefa; Kandemir, Fatih Mehmet (Wiley, 2023)Our experimental objective was to investigate the hepatotoxic effect of vincristine (VCR) administration in rats and determined whether combined therapy with Quercetin (Quer) ensured protection. Five groups with seven rats ... -
Carvacrol protects against λ-Cyhalothrin-induced hepatotoxicity and nephrotoxicity by modulating oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy
İleritürk, Mustafa; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2023)λ-Cyhalothrin, a type II synthetic pyrethroid, has been widely used in households, agriculture, public health, and gardening to control insect pests. Despite its widespread usage, it is known to induce a variety of adverse ... -
Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways
Gür, Cihan; Kandemir, Fatih Mehmet; Çağlayan, Cüneyt; Satıcı, Emine (Elsevier Ireland Ltd, 2022)Paclitaxel (PTX) is a widely used chemotherapeutic drug particularly effective against lung, breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity. The mechanisms underlying PTX ... -
Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats
Varışlı, Behçet; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Ayna, Adnan; Ayna, Adnan; Genç, Aydın; Taysı, Seyithan (Springer Science and Business Media B.V., 2023)Diclofenac (DF) is a non-steroidal anti-inflammatory drug (NSAID) generally prescribed for the treatment of pain. In spite of the widespread use of DF, hepatotoxicity has been reported after its administration. The current ... -
Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate.
Akarsu, Serkan Ali; Gür, Cihan; İleritürk, Mustafa; Akaras, Nurhan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier GmbH, 2023)Heavy metals are one of the environmental pollutants. Lead (Pb) is one of the most common of these heavy metals. In this study, it was aimed at investigating the effects of syringic acid (SA) against testicular toxicity ... -
Effects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation
Tuncer, Sibel Çiğdem; Küçükler, Sefa; Gür, Cihan; Aygörmez, Serpil; Kandemir, Fatih Mehmet (Springer Science and Business Media B.V., 2023)Cadmium (Cd) is a strong toxic agent and causes serious damage to testicular tissues. Chrysin (CHR) is a natural flavonoid with many effective properties, especially antioxidant, anti-inflammatory and anti-apoptotic ... -
Effects of sinapic acid on lead acetate-induced oxidative stress, apoptosis and inflammation in testicular tissue
Tuncer, Sibel Çiğdem; Akarsu, Serkan Ali; Küçükler, Sefa; Gür, Cihan; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2023)In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular tissue of rats was tried to be determined. ... -
Evaluation of protective effects of quercetin against cypermethrin-induced lung toxicity in rats via oxidative stress, inflammation, apoptosis, autophagy, and endoplasmic reticulum stress pathway
İleritürk, Mustafa; Kandemir, Özge; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2022)Cypermethrin (CYP), a type II synthetic pyrethroid, is the most widely used insecticide worldwide. Inhalation of it may cause side effects. This study is aimed to examine potential protection of quercetin (QUE) which is a ... -
Evaluation of the levels of metalloproteinases as well as markers of oxidative stress and apoptosis in lung tissues after malathion and rutin administrations to rats
Gür, Cihan; Kandemir, Fatih Mehmet (Bingöl Üniversitesi Fen Bilimleri Enstitüsü, 2022)Malathion (MLT) is an important environmental pollutant in the organophosphate class. Rutin (RUT), on the other hand, is one of the flavonoid family members whose effectiveness against various toxic agents has been extensively ... -
Hesperidin attenuates oxidative stress, inflammation, apoptosis, and cardiac dysfunction in sodium fluoride‐Induced cardiotoxicity in rats
Varışlı, Behçet; Darendelioğlu, Ekrem; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Ayna, Adnan; Genç, Aydın; Kandemir, Özge (Springer, 2022)Excessive fluoride intake has been reported to cause toxicities to brain, thyroid, kidney, liver and testis tissues. Hesperidin (HSP) is an antioxidant that possesses anti-allergenic, anti-carcinogenic, anti-oxidant and ... -
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress
İleritürk, Mustafa; Kandemir, Özge; Akaras, Nurhan; Şimsek, Hasan; Genç, Aydın; Kandemir, Fatih Mehmet (Elsevier Inc., 2023)Paclitaxel (PTX) is widely used to treat a number of malignancies, although it has toxic side effects. Hesperidin (HES) has a wide range of biological and pharmacological properties, including anti-inflammatory and antioxidant ... -
The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats
Varışlı, Behçet; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Bayav, Ibrahim; Genç, Aydın (Springer, 2022)Background Methotrexate (MT) is a broadly used chemotherapeutic drug however its clinical use is confronted with several forms of toxicities containing testicular damage. The current study assessed the ameliorative effects ... -
Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation
Yardım, Ahmet; Gür, Cihan; Çomaklı, Selim; Özdemir, Selçuk; Küçükler, Sefa; Çelik, Hamit; Kandemir, Fatih Mehmet (Elsevier B.V., 2022)Bortezomib (BTZ), a proteasome inhibitor, causes dose-limiting peripheral neuropathy in humans. Berberine (BBR), which has various biological and pharmacological properties, is known to have neuroprotective properties. The ... -
Molecular and biochemical investigation of the protective effects of rutin against liver and kidney toxicity caused by malathion administration in a rat model
Gür, Cihan; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2023)Widely used malathion (MLT) causes environmental pollution, leading to toxicity in many living things, including humans. Rutin (RUT) is a flavonoid with various biological properties. In the present study, the protective ... -
Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
Kızıl, Hamit Emre; Çağlayan, Cüneyt; Darandelioğlu, Ekrem; Ayna, Adnan; Gür, Cihan; Kandemir, Fatih Mehmet; Küçükler, Sefa (Springer, 2023)Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe ... -
Morin provides therapeutic effect by attenuating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and oxidative DNA damage in testicular toxicity caused by ifosfamide in rats
Çakmak, Fatma; Küçükler, Sefa; Gür, Cihan; Çomaklı, Selim; İleritürk, Mustafa; Kandemir, Fatih Mehmet (Mashhad : Mashhad University of Medical Sciences, 2023)Objectives: In the present study, it was evaluated whether morin has a protective effect on testicular toxicity caused by ifosfamide (IFOS), which is used in the treatment of various malignancies. Materials and methods: ... -
Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy
Yıldız, Mustafa Onur; Çelik, Hamit; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Bayav, İbrahim; Genç, Aydın; Kandemir, Özge (Neurotoxicology, 2022)Fluoride is an element with toxic properties and has been proven to have some adverse effects on many soft tissues, including brain tissue. This study aims to evaluate the protective effects of hesperidin on sodium fluoride ... -
Neuroprotective effects of 18 beta-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway
Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Ayna, Adnan; Gür, Cihan; Küçükler, Sefa; Darendelioğlu, Ekrem (Springer, 2022)The exposure to bisphenol A (BPA) is inevitable owing to its common use in the production of polycarbonate plastics. Studies to reduce side effects are gaining importance since BPA causes severe toxicities in important ... -
The possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin
Akdemir, Fazile Nur Ekinci; Yıldırım, Serkan; Kandemir, Fatih Mehmet (Springer Science and Business Media Deutschland GmbH, 2022)In this, it was aimed to determine the possible beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four ...
