Browsing by Author "Küçükler, Sefa"
Now showing items 1-20 of 26
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The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death
Kankılıç, Nazım Abdülkadir; Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Gencer, Selman; Kandemir, Fatih Mehmet (Elsevier Ltd, 2024)Bortezomib is a proteasome inhibitor antineoplastic agent that was the first to be approved for cancer treatment. One of bortezomib's most prominent dose-limiting effects is nephrotoxicity; the underlying mechanism is ... -
Ameliorative effects of sinapic acid against vancomycin-induced testicular oxidative damage, apoptosis, inflammation, testicular histopathologic disorders and decreased epididymal sperm quality
Akarsu, Serkan Ali; İleritürk, Mustafa; Küçükler, Sefa; Akaras, Nurhan; Gür, Cihan; Kandemir, Fatih Mehmet (Elsevier, 2024)In this study, it was aimed to determine the effect of sinapic acid (SNP), a polyphenol with antioxidant, anti-inflammatory and antibacterial properties, on testicular damage caused by vancomycin (VCM), a widely used ... -
Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO-1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways
Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier B.V., 2023)Cadmium (Cd) is a toxic heavy metal that targets the kidney directly in the body. Chrysin (CHR) is a natural flavonoid with many properties such as antioxidant, anti-inflammatory and anti-apoptotic. The current study ... -
Beneficial effects of quercetin on vincristine-induced liver injury in rats: Modulating the levels of Nrf2/HO-1, NF-kB/STAT3, and SIRT1/PGC-1α
Çomaklı, Selim; Özdemir, Selçuk; Küçükler, Sefa; Kandemir, Fatih Mehmet (Wiley, 2023)Our experimental objective was to investigate the hepatotoxic effect of vincristine (VCR) administration in rats and determined whether combined therapy with Quercetin (Quer) ensured protection. Five groups with seven rats ... -
Carvacrol Reduces Mercuric Chloride-Induced Testicular Toxicity by Regulating Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histopathological Changes
Şimşek, Hasan; Gür, Cihan; Küçükler, Sefa; İleritürk, Mustafa; Akaras, Nurhan; Öz, Mehmet; Kandemir, Fatih Mehmet (Springer, 2023)Mercuric chloride (HgCl2) is a heavy metal that is toxic to the human body. Carvacrol (CAR) is a flavonoid found naturally in plants and has many biological and pharmacological activities including anti-inflammatory, ... -
Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate.
Akarsu, Serkan Ali; Gür, Cihan; İleritürk, Mustafa; Akaras, Nurhan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier GmbH, 2023)Heavy metals are one of the environmental pollutants. Lead (Pb) is one of the most common of these heavy metals. In this study, it was aimed at investigating the effects of syringic acid (SA) against testicular toxicity ... -
Effects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation
Tuncer, Sibel Çiğdem; Küçükler, Sefa; Gür, Cihan; Aygörmez, Serpil; Kandemir, Fatih Mehmet (Springer Science and Business Media B.V., 2023)Cadmium (Cd) is a strong toxic agent and causes serious damage to testicular tissues. Chrysin (CHR) is a natural flavonoid with many effective properties, especially antioxidant, anti-inflammatory and anti-apoptotic ... -
Effects of sinapic acid on lead acetate-induced oxidative stress, apoptosis and inflammation in testicular tissue
Tuncer, Sibel Çiğdem; Akarsu, Serkan Ali; Küçükler, Sefa; Gür, Cihan; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2023)In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular tissue of rats was tried to be determined. ... -
Effects of zingerone on rat induced testicular toxicity by sodium arsenite via oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, and autophagy pathways
Tuncer, Sibel Çiǧdem; Gür, Cihan; Küçükler, Sefa; Akarsu, Serkan Ali; Kandemir, Fatih Mehmet (Mashhad University of Medical Sciences, 2024)This study aimed to investigate the effects of zingerone (ZNG) treatment on testicular toxicity in rats induced by sodium arsenite (SA). Materials and Methods: In the study, five groups were formed (n=7) and the experimental ... -
Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats
Küçükler, Sefa; Çağlayan, Cüneyt; Özdemir, Selçuk; Çomaklı, Selim; Kandemir, Fatih Mehmet (Springer, 2024)Chlorpyrifos (CPF), considered one of the most potent organophosphates, causes a variety of human disorders including neurotoxicity. The current study was designed to evaluate the efficacy of hesperidin (HSP) in ameliorating ... -
Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation
Yardım, Ahmet; Gür, Cihan; Çomaklı, Selim; Özdemir, Selçuk; Küçükler, Sefa; Çelik, Hamit; Kandemir, Fatih Mehmet (Elsevier B.V., 2022)Bortezomib (BTZ), a proteasome inhibitor, causes dose-limiting peripheral neuropathy in humans. Berberine (BBR), which has various biological and pharmacological properties, is known to have neuroprotective properties. The ... -
Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
Kızıl, Hamit Emre; Çağlayan, Cüneyt; Darandelioğlu, Ekrem; Ayna, Adnan; Gür, Cihan; Kandemir, Fatih Mehmet; Küçükler, Sefa (Springer, 2023)Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe ... -
Morin provides therapeutic effect by attenuating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and oxidative DNA damage in testicular toxicity caused by ifosfamide in rats
Çakmak, Fatma; Küçükler, Sefa; Gür, Cihan; Çomaklı, Selim; İleritürk, Mustafa; Kandemir, Fatih Mehmet (Mashhad : Mashhad University of Medical Sciences, 2023)Objectives: In the present study, it was evaluated whether morin has a protective effect on testicular toxicity caused by ifosfamide (IFOS), which is used in the treatment of various malignancies. Materials and methods: ... -
Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage
Yılmaz, Selçuk; Küçükler, Sefa; Şi̇mşek, Hasan; Aygörmez, Serpil; Kandemir, Fatih Mehmet (Ondokuz Mayis Universitesi, 2024)Colistin is used in treatment against gram-negative bacteria. It causes toxic effects due to oxidative stress in a dose-dependent manner. Naringin is a flavonoid with strong antioxidant properties found naturally in many ... -
Naringin protects against paclitaxel-induced toxicity in rat testicular tissues by regulating genes in pro-inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways
Kankılıç, Nazım Abdülkadir; Küçükler, Sefa; Gür, Cihan; Akarsu, Serkan Ali; Akaras, Nurhan; Şimşek, Hasan; İleritürk, Mustafa; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2024)Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and ... -
Neuroprotective effects of 18 beta-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway
Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Ayna, Adnan; Gür, Cihan; Küçükler, Sefa; Darendelioğlu, Ekrem (Springer, 2022)The exposure to bisphenol A (BPA) is inevitable owing to its common use in the production of polycarbonate plastics. Studies to reduce side effects are gaining importance since BPA causes severe toxicities in important ... -
Oxidative stress parameters in dogs naturally infected with sarcoptic mange
Yanar, Kerim Emre; Küçükler, Sefa; Eren, Emre; Eroğlu, Muhammed Sertaç; İIgün, Murat; Gür, Cihan; Kandemir, Fatih Mehmet; Aktaş, Mustafa Sinan (Facultad de Ciencias Agrarias UdeA, 2023)Scabies is one of the most common diseases in dogs. It threatens both animals and humans due to its zoonotic potential. Objective: The purpose of this study was to evaluate the oxidant/antioxidant balance with hematological ... -
The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach
Akaras, Nurhan; İleritürk, Mustafa; Gür, Cihan; Küçükler, Sefa; Öz, Mehmet; Kandemir, Fatih Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)This study aimed to determine the potential protective effects of chrysin (CHR) on experimental cadmium (Cd)-induced lung toxicity in rats. To this end, rats were divided into five groups; Control, CHR, Cd, Cd + CHR25, Cd ... -
Protective effects of naringin on colistin-induced damage in rat testicular tissue: Modulating the levels of Nrf-2/HO-1, AKT-2/FOXO1A, Bax/Bcl2/Caspase-3, and Beclin-1/LC3A/LC3B signaling pathways
Kankılıç, Nazım Abdülkadir; Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; İleritürk, Mustafa; Küçükler, Sefa; Akarsu, Serkan A.; Kandemir, Fatih M. (John Wiley and Sons Inc, 2024)Antimicrobial agent resistance has become a growing health issue across the world. Colistin (COL) is one of the drugs used in the treatment of multidrug-resistant bacteria resulting in toxic effects. Naringin (NRG), a ... -
Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach
Şimşek, Hasan; Küçükler, Sefa; Gür, Cihan; Akaras, Nurhan; Kandemir, Fatih Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)Lead acetate (PbAc) is one of the top five most dangerous toxic heavy metals, particularly leading to kidney damage and posing serious health risks in both humans and animals. Sinapic acid (SNP) is a naturally occurring ...
