Browsing by Author "Hazer, Baki"
Now showing items 1-12 of 12
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Antisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer types
Kılıçay, Ebru; Erdal, Ebru; Hazer, Baki; Türk, Mustafa; Denkbaş, Emir Baki (Taylor & Francis Ltd, 2016)Amphiphilic poly(3-hydroxylalkanoate) (PHA) copolymers find interesting applications in drug delivery. The aim of this study was to prepare nucleic acid adsorbed on (PHB-b-PEG-NH2) nanoparticle platform for gene delivery. ... -
Biocompatible PVC Derivatives with Some Natural Substances for Potential Active Food Packaging Materials
Hazer, Baki; Karahaliloğlu, Zeynep (ACS Publications, 2023)Monoethyl fumarate (mef), bovine serum albumin (bsa), abietic acid (ab), morphine (mrp), aspirin (asp), indole (ind), and lysozyme (lysz) functionalized poly vinyl chloride (PVC) samples were synthesized for possible ... -
Concanavaline A conjugated bacterial polyester-based PHBHHx nanoparticles loaded with curcumin for breast cancer therapy
Kılıçay, Ebru; Karahaliloğlu, Zeynep; Hazer, Baki; Tekin, İshak Özel; Denkbaş, Emir Baki (Taylor & Francis, 2016)The aim of this study was to evaluate therapeutic potential of curcumin-loaded poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) PHBHHx nanoparticles (CUR-NPs) and concanavaline A conjugated curcumin-loaded NPs (ConA-CUR-NPs) ... -
Enhanced antitumor activity of epigallocatechin gallate-conjugated dual-drug-loaded polystyrene-polysoyaoil-diethanol amine nanoparticles for breast cancer therapy
Karahaliloğlu, Zeynep; Kılıçay, Ebru; Alpaslan, Pınar; Hazer, Baki; Denkbaş, Emir Baki (Sage Publications Ltd, 2018)The development of novel combination anticancer drug delivery systems is an important step to improve the effectiveness of anticancer treatment in metastatic breast cancer and to overcome increased toxicity of the currently ... -
Herceptin-conjugated magnetic polystyrene-Agsbox nanoparticles as a theranostic agent for breast cancer
Karahaliloğlu, Zeynep; Kılıçay, Ebru; Hazer, Baki (SAGE Publications Ltd, 2022)Breast cancer is a malignant tumor, which has derived from cells of the breast. Further, a relatively rapid metastasis, and resistance development against all the conventional drug combinations are major clinical issues ... -
Impregnation of polyethylene terephthalate (PET) grafts with BMP-2 loaded functional nanoparticles for reconstruction of anterior cruciate ligament
Karahaliloğlu, Zeynep; Ercan, Batur; Hazer, Baki (Taylor & Francis, 2023)Current artificial ligaments based on polyethylene terephthalate (PET) are associated with some disadvantages due to their hydrophobicity and low biocompatibility. In this study, we aimed to modify the surface of PET using ... -
In vitro evaluation of antisense oligonucleotide functionalized core-shell nanoparticles loaded with -tocopherol succinate
Kılıçay, Ebru; Karahalıloğlu, Zeynep; Alpaslan, Pınar; Hazer, Baki; Denkbaş, Emir Baki (Taylor & Francis, 2017)Antisense oligonucleotide (ASO)-conjugated--tocopherol succinate (TCS)-loaded-poly(lactic acid)-g-poly(ethylene glycol) nanoparticles (ASO-TCS-PLA-PEG NPs), with the ratio of polymer/TCS of 10:2.5, 10:5, 10:7 (w/w) were ... -
PLinaS-g-PEG coated magnetic nanoparticles as a contrast agent for hepatocellular carcinoma diagnosis
Karahaliloǧlu, Zeynep; Kılıçay, Ebru; Hazer, Baki (Taylor and Francis Inc., 2020)Among many different types of fabricated nanoparticles, magnetic iron oxide nanoparticles (MNPs) have unique physical and chemical properties and have been widely used due to theirs enhanced permeability and retention ... -
Poly(vinyl chloride) Derived Food Packaging Applications with Antioxidative and Anticancer Properties
Hazer, Baki; Karahaliloğlu, Zeynep; Ashby, Richard D. (American Chemical Society, 2023)Novel poly(vinyl chloride) (PVC) polymer derivatives based on the natural antioxidants vanillic acid, cinnamic acid, coumaric acid, caffeic acid, and naringin were prepared and characterized for their chemical structures, ... -
Potent bioactive bone cements impregnated with polystyrene-g-soybean oil-AgNPs for advanced bone tissue applications
İlhan, Elif; Karahaliloğlu, Zeynep; Kılıçay, Ebru; Hazer, Baki; Denkbaş, Emir Baki (Taylor & Francis, 2020)Postoperative infection in orthopaedic and trauma surgery is one of the most feared complications. Recently, the high prevalence of multidrug-resistant bacteria has made the antibiotic treatment ineffective; thus novel ... -
The preparation of chitosan membrane improved with nanoparticles based on unsaturated fatty acid for using in cancer-related infections
Kızaloğlu, Abdullah; Kılıçay, Ebru; Karahaliloǧlu, Zeynep; Hazer, Baki; Denkbaş, Emir Baki (SAGE Publications Ltd, 2020)This study includes the design of a chitosan membrane decorated with unsaturated fatty acid–based carrier system for cancer treatment and antibacterial application. For this, polystyrene-graft-polyoleic acid-graft-polyethylene ... -
Prevention of urinary infection through the incorporation of silver-ricinoleic acid-polystyrene nanoparticles on the catheter surface
Koç, Hazal; Kılıçay, Ebru; Karahaliloğlu, Zeynep; Hazer, Baki; Denkbaş, Emir B. (Karatekin University, 2021)Nosocominal infections associated with biofilm formation on urinary catheters cause serious complications. The aim of this study was to investigate the feasibility of the polyurethane (PU) catheter modified with tetracycline ...
