Browsing by Author "Akaras, Nurhan"
Now showing items 1-14 of 14
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(1 → 3)-β-d-glucan enhances the toxicity induced by Bortezomib in rat testis
Abuç, Özlem Özgül; Koç, Kübra; Bal, Tuğba; Geyikoǧlu, Fatime; Atilay, Hilal; Erol, Hüseyin Serkan; Yiğit, Serdar; Gül, Murat; Akaras, Nurhan (Blackwell Publishing Ltd, 2020)We aimed to determine the possible effects of the antioxidant agent (1 → 3)-β-D-glucan on bortezomib-induced rat testis damage. We used five groups of rats; control, (1 → 3)-β-D-glucan (75 mg/kg), bortezomib group, bortezomib ... -
Acacetin ameliorates acetylsalicylic acid-induced gastric ulcer in rats by interfering with oxidative stress, inflammation, and apoptosis
Şimşek, Hasan; Akaras, Nurhan (Ali Cangül, 2023)Gastric ulcer (GU) is a benign lesion in which excessive acid and pepsin activity affects the mucosal ep- ithelium and is common worldwide. Gastrointestinal disturbances come to the fore among the side effects observed in ... -
Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO-1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways
Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier B.V., 2023)Cadmium (Cd) is a toxic heavy metal that targets the kidney directly in the body. Chrysin (CHR) is a natural flavonoid with many properties such as antioxidant, anti-inflammatory and anti-apoptotic. The current study ... -
Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite-induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats
Gür, Cihan; Akarsu, Serkan Ali; Akaras, Nurhan; Tuncer, Sibel Çiğdem (Wiley, 2023)Arsenic (As) is a highly toxic metalloid. Carvacrol (CAR) is the active ingredient of Lamiaceae plants and has various biological and pharmacological properties. The present study investigated the protective effects of ... -
The effect of platelet-rich plasma injection on post-internal urethrotomy stricture recurrence
Gül, Murat; Akaras, Nurhan (Springer Verlag, 2019)[No abstract available] -
Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate.
Akarsu, Serkan Ali; Gür, Cihan; İleritürk, Mustafa; Akaras, Nurhan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier GmbH, 2023)Heavy metals are one of the environmental pollutants. Lead (Pb) is one of the most common of these heavy metals. In this study, it was aimed at investigating the effects of syringic acid (SA) against testicular toxicity ... -
Gossypin protects against renal Ischemia-Reperfusion Injury in rats
Tanyeli, Ayhan; Eraslan, Ersen; Güler, Mustafa Can; Kurt, Nezahat; Akaras, Nurhan (Kafkas University, 2020)Renal injury occurring as a result of renal ischemia-reperfusion may lead to renal failure or even death. The aim of this study is to investigate possible protective effects of Gossypin on tissue damage occurred due to ... -
Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress
İleritürk, Mustafa; Kandemir, Özge; Akaras, Nurhan; Şimsek, Hasan; Genç, Aydın; Kandemir, Fatih Mehmet (Elsevier Inc., 2023)Paclitaxel (PTX) is widely used to treat a number of malignancies, although it has toxic side effects. Hesperidin (HES) has a wide range of biological and pharmacological properties, including anti-inflammatory and antioxidant ... -
A histological and biochemical study of cumulus cells and the oocyte microenviroment in in vitro fertilization patients
Akaras, Nurhan; Demirci, Tuba; Abuç, Özlem Özgül; 0000-0001-9852-8839; Halıcı, Mesut Bünyamin; Kaşali, Kamber (Association of Clinical Biochemistry Specialists (Klinik Biyokimya Uzmanları Derneği), 2021)Objectives: The aim of this study was to investigate the effect of chemical changes in the follicular fluid and histological changes in the cumulus cells of the oocyte microenvironment on the number of oocytes in infertile ... -
A histological and biochemical study of the protective role of hesperidin in testicular ischemia-reperfusion injury
Akaras, Nurhan; Şimşek, Hasan; Ordu, Melike (Ali Cangül, 2023)This study aimed to investigate the possible effects of hesperidin on ischemia-reperfusion (IR) injury applied to rat testis. Methods: Twenty-eight Wistar albino rats were used and divided into four groups of seven each. ... -
Protective effect of astaxanthin and metformin in the liver of rats in which the polycystic ovary syndrome model was formed by giving letrozole
Taştan, Tuǧba Bal; Akaras, Nurhan; Demir, Özlem; Ugan, Rüstem Anıl (Mashhad University of Medical Sciences, 2023)In this study, the effects of astaxanthin on liver tissue in rats with polycystic ovary syndrome (PCOS) were evaluated. Materials and Methods: Fifty-four Spraque-Dawley rats were divided into 9 groups: Groups: Control, ... -
The protective effects of chrysin on cadmium-induced pulmonary toxicity; a multi-biomarker approach
Akaras, Nurhan; İleritürk, Mustafa; Gür, Cihan; Küçükler, Sefa; Öz, Mehmet; Kandemir, Fatih Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)This study aimed to determine the potential protective effects of chrysin (CHR) on experimental cadmium (Cd)-induced lung toxicity in rats. To this end, rats were divided into five groups; Control, CHR, Cd, Cd + CHR25, Cd ... -
Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach
Şimşek, Hasan; Küçükler, Sefa; Gür, Cihan; Akaras, Nurhan; Kandemir, Fatih Mehmet (Springer Science and Business Media Deutschland GmbH, 2023)Lead acetate (PbAc) is one of the top five most dangerous toxic heavy metals, particularly leading to kidney damage and posing serious health risks in both humans and animals. Sinapic acid (SNP) is a naturally occurring ... -
Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes
Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Kandemir, Fatih Mehmet (Elsevier, 2023)Arsenic is widely available in the environment and arsenic toxicity is a public health problem of serious concern worldwide. Zingerone is a promising phytochemical with various pharmacological effects. In this study, the ...
