Browsing by Author "Çomaklı, Selim"
Now showing items 1-4 of 4
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Beneficial effects of quercetin on vincristine-induced liver injury in rats: Modulating the levels of Nrf2/HO-1, NF-kB/STAT3, and SIRT1/PGC-1α
Çomaklı, Selim; Özdemir, Selçuk; Küçükler, Sefa; Kandemir, Fatih Mehmet (Wiley, 2023)Our experimental objective was to investigate the hepatotoxic effect of vincristine (VCR) administration in rats and determined whether combined therapy with Quercetin (Quer) ensured protection. Five groups with seven rats ... -
Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats
Küçükler, Sefa; Çağlayan, Cüneyt; Özdemir, Selçuk; Çomaklı, Selim; Kandemir, Fatih Mehmet (Springer, 2024)Chlorpyrifos (CPF), considered one of the most potent organophosphates, causes a variety of human disorders including neurotoxicity. The current study was designed to evaluate the efficacy of hesperidin (HSP) in ameliorating ... -
Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage in rats through pathways involved in oxidative stress and neuro-inflammation
Yardım, Ahmet; Gür, Cihan; Çomaklı, Selim; Özdemir, Selçuk; Küçükler, Sefa; Çelik, Hamit; Kandemir, Fatih Mehmet (Elsevier B.V., 2022)Bortezomib (BTZ), a proteasome inhibitor, causes dose-limiting peripheral neuropathy in humans. Berberine (BBR), which has various biological and pharmacological properties, is known to have neuroprotective properties. The ... -
Morin provides therapeutic effect by attenuating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and oxidative DNA damage in testicular toxicity caused by ifosfamide in rats
Çakmak, Fatma; Küçükler, Sefa; Gür, Cihan; Çomaklı, Selim; İleritürk, Mustafa; Kandemir, Fatih Mehmet (Mashhad : Mashhad University of Medical Sciences, 2023)Objectives: In the present study, it was evaluated whether morin has a protective effect on testicular toxicity caused by ifosfamide (IFOS), which is used in the treatment of various malignancies. Materials and methods: ...
