Browsing by Author "Çağlayan, Cüneyt"
Now showing items 1-11 of 11
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Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways
Gür, Cihan; Kandemir, Fatih Mehmet; Çağlayan, Cüneyt; Satıcı, Emine (Elsevier Ireland Ltd, 2022)Paclitaxel (PTX) is a widely used chemotherapeutic drug particularly effective against lung, breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity. The mechanisms underlying PTX ... -
Chrysin mitigates diclofenac-induced hepatotoxicity by modulating oxidative stress, apoptosis, autophagy and endoplasmic reticulum stress in rats
Varışlı, Behçet; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Ayna, Adnan; Ayna, Adnan; Genç, Aydın; Taysı, Seyithan (Springer Science and Business Media B.V., 2023)Diclofenac (DF) is a non-steroidal anti-inflammatory drug (NSAID) generally prescribed for the treatment of pain. In spite of the widespread use of DF, hepatotoxicity has been reported after its administration. The current ... -
Hesperidin attenuates oxidative stress, inflammation, apoptosis, and cardiac dysfunction in sodium fluoride‐Induced cardiotoxicity in rats
Varışlı, Behçet; Darendelioğlu, Ekrem; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Ayna, Adnan; Genç, Aydın; Kandemir, Özge (Springer, 2022)Excessive fluoride intake has been reported to cause toxicities to brain, thyroid, kidney, liver and testis tissues. Hesperidin (HSP) is an antioxidant that possesses anti-allergenic, anti-carcinogenic, anti-oxidant and ... -
Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats
Küçükler, Sefa; Çağlayan, Cüneyt; Özdemir, Selçuk; Çomaklı, Selim; Kandemir, Fatih Mehmet (Springer, 2024)Chlorpyrifos (CPF), considered one of the most potent organophosphates, causes a variety of human disorders including neurotoxicity. The current study was designed to evaluate the efficacy of hesperidin (HSP) in ameliorating ... -
The impact of Nrf2/HO-1, caspase-3/Bax/Bcl2 and ATF6/IRE1/PERK/GRP78 signaling pathways in the ameliorative effects of morin against methotrexate-induced testicular toxicity in rats
Varışlı, Behçet; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Bayav, Ibrahim; Genç, Aydın (Springer, 2022)Background Methotrexate (MT) is a broadly used chemotherapeutic drug however its clinical use is confronted with several forms of toxicities containing testicular damage. The current study assessed the ameliorative effects ... -
Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways
Kızıl, Hamit Emre; Çağlayan, Cüneyt; Darandelioğlu, Ekrem; Ayna, Adnan; Gür, Cihan; Kandemir, Fatih Mehmet; Küçükler, Sefa (Springer, 2023)Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe ... -
Neuromodulatory effects of hesperidin against sodium fluoride-induced neurotoxicity in rats: Involvement of neuroinflammation, endoplasmic reticulum stress, apoptosis and autophagy
Yıldız, Mustafa Onur; Çelik, Hamit; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Gür, Cihan; Bayav, İbrahim; Genç, Aydın; Kandemir, Özge (Neurotoxicology, 2022)Fluoride is an element with toxic properties and has been proven to have some adverse effects on many soft tissues, including brain tissue. This study aims to evaluate the protective effects of hesperidin on sodium fluoride ... -
Neuroprotective effects of 18 beta-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway
Çağlayan, Cüneyt; Kandemir, Fatih Mehmet; Ayna, Adnan; Gür, Cihan; Küçükler, Sefa; Darendelioğlu, Ekrem (Springer, 2022)The exposure to bisphenol A (BPA) is inevitable owing to its common use in the production of polycarbonate plastics. Studies to reduce side effects are gaining importance since BPA causes severe toxicities in important ... -
Protective effect of naringin against oxaliplatin-induced peripheral neuropathy in rats: A behavioral and molecular study
Semis, Halil S.; Kandemir, Fatih M.; Çağlayan, Cüneyt; Kaynar, Özgür; Genç, Aydın; Arıkan, Şefik M. (Wiley, 2022)Oxaliplatin (OXL) is a chemotherapeutic drug used for metastatic and other types of cancer, but it causes peripheral neuropathy as a dose-limiting side effect. Herein, we used the rat model of OXL-induced peripheral ... -
Protective effects of naringin against oxaliplatin-induced testicular damage in rats: Involvement of oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, and histopathology
Akaras, Nurhan; Gür, Cihan; Çağlayan, Cüneyt; Kandemir, Fatih Mehmet (Mashhad University of Medical Sciences, 2024)Oxaliplatin (OXL) is a platinum-based chemotherapeutic agent widely used in the treatment of colorectal cancer. Unfortunately, this important drug also causes unwanted side effects such as neuropathy, ototoxicity, and ... -
Therapeutic Potential of Silymarin in Mitigating Paclitaxel-Induced Hepatotoxicity and Nephrotoxicity: Insights into Oxidative Stress, Inflammation, and Apoptosis in Rats
Yakut, Seda; Atcalı, Tuğçe; Çağlayan, Cüneyt; Ulucan, Aykut; Kandemir, Fatih Mehmet; Kara, Adem; Anuk, Turgut (Galenos Publishing House, 2024)Paclitaxel (PAX) is a widely used chemotherapy drug for various cancer types but often induces significant toxicity in multiple organ systems. Silymarin (SIL), a natural flavonoid, has shown therapeutic potential due to ...
