Effect of human gestational diabetes mellitus on arterial stiffness

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dc.contributor.authorİnci, Sinan
dc.contributor.authorNar, Gökay
dc.contributor.authorBalkan, Fevzi
dc.contributor.authorAksan, Gökhan
dc.contributor.authorDe?irmenci, Hüsnü
dc.contributor.authorHamur, Hikmet
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:22:30Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:22:30Z
dc.date.issued2014
dc.departmentTıp Fakültesi
dc.description.abstractBackground. The present study aims to evaluate the parameters for aortic stiffness by comparing gestational diabetes mellitus (GDM) with a healthy control group via transthoracic echocardiography. Methods. This was a cross-sectional study involving monitoring of 62 pregnant women (33 with GDM and 29 with uncomplicated pregnancy as controls) during the third trimester. The aortic strain, aortic distensibility, and aortic stiffness values were measured via transthoracic echocardiography. Measurements of GDM group were repeated after 6 months. Results. Blood pressure levels, heart rate, and basic echocardiography were similar in both groups, but BMI was significantly higher in the GDM group (p <0.001). Whereas, aortic strain and distensibility were significantly lower in the GDM group (p <0.001). Aortic stiffness index was significantly higher in the GDM group (p <0.001). Aortic stiffness parameters did not exhibit any significant difference between the insulin-receiving GDM group and the diet-controlled GDM group. Postprandial glucose levels were correlated positively with the aortic stiffness index (p=0.04) and negatively with the level of aortic strain (p<0.01) and distensibility (p=0.03). The aortic stiffness in normoglycemic postpartum group at 6th month showed a significant improvement (p<0.001); but not in hyperglycemic postpartum group. Conclusion. Arterial stiffness was increased in women with GDM compared to the control group. A correlation between postprandial glucose and arterial stiffness was found. The aortic stiffness can be affected irreversibly from increased clinical and subclinical levels of glucose in postpartum period.
dc.identifier.doi10.4183/aeb.2014.352
dc.identifier.endpage362en_US
dc.identifier.issn1841-0987
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage352en_US
dc.identifier.urihttps://dx.doi.org/10.4183/aeb.2014.352
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2576
dc.identifier.volume10en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherActa Endocrinologica Foundation
dc.relation.ispartofActa Endocrinologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectArterial Stiffness
dc.subjectGestational Diabetes
dc.subjectTransthoracic Echocardiography
dc.titleEffect of human gestational diabetes mellitus on arterial stiffness
dc.typeArticle

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