Evaluation of Hemoglobin, Albumin, Lymphocyte, and Platelet Score, Neutrophil-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio in Pediatric Patients with Rotavirus Enteritis

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dc.authorid0000-0002-3983-0090
dc.contributor.authorDemirtaş, Mehmet Semih
dc.contributor.authorMemiş, Sebahattin
dc.contributor.authorKocagozoğlu, Sevim Gonca
dc.date.accessioned2025-07-25T06:33:08Z
dc.date.available2025-07-25T06:33:08Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractObjective: Rotavirus enteritis (RV-e) continues to play a major role in hospitalization and morbidity in patients with acute gastroenteritis (AGE). Identifying new biomarkers that can improve risk assessment of RV-e is crucial for effective disease management. This study aimed to evaluate systemic immune/inflammatory index (SII) markers and hemoglobin, albumin, lymphocyte, and platelet score (HALP score) in children with RV-e. Materials and Methods: This retrospective cohort study was conducted in the pediatric emergency outpatient clinic (PEOC) of a tertiary-level training and research hospital, involving 816 patients. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and HALP score were used to evaluate inflammation in cases of rotavirus (RV) and other types of enteritis. Results: A total of 816 patients were included in the study, of whom 45.3% were female and 54.7% were male. The hospitalization rate due to RV-e was higher than that of non- RV-e cases, with 47.5% (n=85) of RV-e patients being hospitalized (p<0.001). Both NLR and PLR was elevated in hospitalized patients within the RV-e group (p<0.001 for both). Hospitalization was found to be 1.45 times more likely (95% confidence interval [CI]: 1.09- 1.94) among patients with low HALP scores, six times more likely (95% CI: 3.52-10.26) in patients with RV-e, and 2.88 times more likely (95% CI: 1.40-5.88) in children under five years of age. Conclusion: This study demonstrated that the frequency of hospitalization increased in patients with low HALP scores. We think that the HALP score may serve as a simple and rapid marker to aid clinicians in early treatment planning, especially for patients diagnosed with RV-e in emergency settings.
dc.identifier.doi10.14744/cpr.2024.51648
dc.identifier.endpage35
dc.identifier.issn2980-2156
dc.identifier.issue1
dc.identifier.startpage28
dc.identifier.urihttps://dx.doi.org/ 10.14744/cpr.2024.51648
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13581
dc.identifier.volume47
dc.identifier.wosWOS:001417617200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorDemirtaş, Mehmet Semih
dc.institutionauthorMemiş, Sebahattin
dc.institutionauthorid0000-0003-2965-1811
dc.institutionauthorid0000-0002-3829-9218
dc.language.isoen
dc.publisherErciyes Medical Journal
dc.relation.ispartofJournal of Clinical Practice and Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRotavirus
dc.subjectGastroenteritis
dc.subjectChildren
dc.subjectHALP Score (Hemoglobin
dc.subjectAlbumin
dc.subjectLymphocyte
dc.subjectand Platelet Score)
dc.subjectPlatelet-to-lymphocyte Ratio (PLR)
dc.subjectNeutrophil-tolymphocyte Ratio (NLR)
dc.subjectSystemic Immune/inflammatory Index Markers
dc.titleEvaluation of Hemoglobin, Albumin, Lymphocyte, and Platelet Score, Neutrophil-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio in Pediatric Patients with Rotavirus Enteritis
dc.typeArticle

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