Determination of Antimicrobial Activity of Cream Formulation Developed with Hibiscus rosa-sinensis Extract and Probiotic
| dc.authorid | 0000-0003-4010-8465 | |
| dc.authorid | 0000-0002-3638-1306 | |
| dc.contributor.author | Sağlam, Ali | |
| dc.contributor.author | Aşan Özüsağlam, Meltem | |
| dc.contributor.author | Çelik, İrem | |
| dc.date.accessioned | 2024-03-20T08:18:01Z | |
| dc.date.available | 2024-03-20T08:18:01Z | |
| dc.date.issued | 2023 | |
| dc.department | Sabire Yazıcı Fen Edebiyat Fakültesi | |
| dc.description.abstract | Medicinal plants are an indispensable source of new and effective pharmaceutical products. In the study, the biological activities of water extract obtained from the H. rosa-sinensis leaf was determined and its potential for use in the pharmaceutical and cosmetic industries was investigated. Disc diffusion assay and micro-dilution method against clinical origin test microorganisms were used to assess biological activity. The Extract showed a zone of inhibition on the tested bacteria and yeasts in the 6.85 mm to 10.74 mm range. MIC and MBC or MFC values of the Extract was determined as 6.25-12.50 µg/µL and 12.50-50 µg/µL. Then, the cream formulation containing H. rosa-sinensis leaf water extract and/or human milk originated probiotic candidate Limosilactobacillus fermentum MA-7 strain have been developed. The Extract and probiotic containing cream formulations showed variable antibacterial and antifungal effects on the tested clinical originated microorganisms. The highest inhibition zone diameters of Cream + Extract + Probiotic formulation group was obtained against Candida glabrata RSKK 04019 (9.09 mm) and Escherichia coli O157:H7 (9.04 mm). The results indicate that L. fermentum MA-7 and H. rosa-sinensis water extract, alternative to synthetic antimicrobials, may be used as a natural bioactive ingredient in daily personal care and clinical applications in the near futu | |
| dc.identifier.doi | 10.53518/mjavl.1327299 | |
| dc.identifier.endpage | 132 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 126 | en_US |
| dc.identifier.uri | https:/dx.doi.org10.53518/mjavl.1327299 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/11487 | |
| dc.identifier.volume | 13 | en_US |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.publisher | Kyrgyz-Turkish Manas University | |
| dc.relation.ispartof | Manas Journal of Agriculture Veterinary and Life Sciences | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Camellia | |
| dc.subject | Cream Formulation | |
| dc.subject | Extract Natural additive Probiotic | |
| dc.title | Determination of Antimicrobial Activity of Cream Formulation Developed with Hibiscus rosa-sinensis Extract and Probiotic | |
| dc.type | Article |
