Biomarkers of Vitamin D Sufficiency: Vitamin D Metabolite Levels do not depend on 25-Hydroxyvitamin D2 levels in Healthy Turkish Individuals

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dc.contributor.authorYavaş, Cüneyd
dc.contributor.authorHekim, Nezih
dc.contributor.authorKarcıoğlu Batur, Lütfiye
dc.contributor.authorEröz, Recep
dc.date.accessioned2025-07-25T07:43:41Z
dc.date.available2025-07-25T07:43:41Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractPatient-specific factors may influence the adequate supplemental vitamin D dose. In this study, we evaluated the relationship between 25(OH)D(2 )and free vitamin D levels and vitamin D deficiency in a healthy Turkish population. Method: Blood samples were obtained from 92 healthy adults aged >= 18 years. Total 25(OH)D was determined by CMIA. Serum 25(OH)D-3 and D(2 )levels were measured by LC-MS. Free 25(OH)D was calculated according to the Bikle method. Results: In 54% of the participants, 25(OH)D(3)levels were below 20 ng/mL. Those with 20 ng/mL or higher had higher mean serum 25(OH)D(3)and free vitamin D levels (P<0.001). Mean 25(OH)D(2)concentration did not differ according to deficiency criteria. Serum 25(OH)D2 levels were consistent regardless of free vitamin D concentrations. Conclusions: Serum 25(OH)D-3 and free vitamin D concentrations measured by LC-MS indicate deficiency by influencing the total 25(OH)D(3)concentration. However, serum 25(OH)D(2 )concentration did not differ between individuals and does not directly indicate deficiency.
dc.identifier.doi10.18521/ktd.1560608
dc.identifier.endpage90
dc.identifier.issn1309-3878
dc.identifier.issue1
dc.identifier.startpage84
dc.identifier.urihttps://dx.doi.org/10.18521/ktd.1560608
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13585
dc.identifier.volume17
dc.identifier.wosWOS:001509016800011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorEröz, Recep
dc.language.isoen
dc.publisherDuzce University
dc.relation.ispartofKonuralp Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAortic Dissection
dc.subjectComputed Tomographic Aortogram
dc.subjectCritical Stenosis in Coronary Arteries
dc.subjectNon-ST-Elevation Myocardial Infarction
dc.titleBiomarkers of Vitamin D Sufficiency: Vitamin D Metabolite Levels do not depend on 25-Hydroxyvitamin D2 levels in Healthy Turkish Individuals
dc.typeArticle

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