Evaluation of The Effects of Tarantula Cubensis Alcohol Extract and Sorafenib Treatments on P21 Protein, Total Antioxidant Capacity and Metabolic Profile in Experimental Rats Hepatocellular Carcinoma

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dc.authorid0000-0001-5811-9571
dc.authorid0000-0001-8034-8266
dc.authorid0000-0003-4698-9291
dc.authorid0000-0002-1595-0557
dc.contributor.authorVanlı, Serdar
dc.contributor.authorKurtoğlu, Firuze
dc.contributor.authorSucarıklı Alan, Beyza
dc.contributor.authorAkçakavak, Gökhan
dc.contributor.authorÖzdemir, Özgür
dc.date.accessioned2025-07-28T11:45:30Z
dc.date.available2025-07-28T11:45:30Z
dc.date.issued2024
dc.departmentVeteriner Fakültesi
dc.description.abstractHepatocellular carcinoma (HCC) is defined as the sixth most common cancer type and the third most common cancer type in terms of cancer-related deaths. Tarantula cubensis alcohol extract (TCAE, Theranekron) is a homeopathic medicine frequently used in veterinary medicine in the treatment of papilloma, mammary adenocarcinoma and necrotic disorders. The present study aimed to reveal the treatment effectiveness of TCAE and Sorafenib (S) in HCC induced by Diethylnitrosamine (DEN) and N-nitrosomorpholine (NMOR)-induced HCC in rats. Rats were randomly divided into 7 groups: Control (C), Control + TCAE (CT), Control + S (CS), Cancer Control (CC), CC+TCAE (CCT), CC+S (CCS), CC+TCAE+S (CCTS). In the CC group, the values for glucose, triglyceride (TG) and total antioxidant capacity (TAC) values were found to be significantly higher than in all other groups (p<0.001), while the p21 levels were found to be significantly lower (p<0.05). It determined an increase in serum p21 levels (p<0.05) and a significant decrease in glucose and TG levels (p<0.001) in the CCT, CCS and CCTS groups compared to the CC group. Histopathological examination revealed that the CC group showed cancer morphology, and the treatment groups caused a decrease in tumor incidence and size. As a result, it can be said that TCAE can be used alone and/or combined with chemotherapy drugs to reveal antiproliferative effects on cancer cells in HCC. Sorafenib and TCAE combination therapy may potentially synergize to improve the magnitude and durability of antitumor responses in patients with HCC.
dc.identifier.doi10.53518/mjavl.1548809
dc.identifier.endpage209
dc.identifier.issn1694-7932
dc.identifier.issue2
dc.identifier.startpage201
dc.identifier.urihttps://dx.doi.org/10.53518/mjavl.1548809
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13616
dc.identifier.volume14
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAkçakavak, Gökhan
dc.language.isoen
dc.relation.ispartofManas Journal of Agriculture Veterinary and Life Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiethylnitrosamine
dc.subjectHepatocellular carcinoma
dc.subjectTarantula cubensis alcoholic extract
dc.subjectp21
dc.subjectN-nitrosomorpholine
dc.titleEvaluation of The Effects of Tarantula Cubensis Alcohol Extract and Sorafenib Treatments on P21 Protein, Total Antioxidant Capacity and Metabolic Profile in Experimental Rats Hepatocellular Carcinoma
dc.typeArticle

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