4-Methyl morpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, and CoMFA study
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Chinese Chemical Society Taiwan
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecular H-bonds. X-ray Crystallography, FT-IR, and 1H and 13C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained.
Açıklama
Tunç, Tuncay ( Aksaray, Yazar )
Anahtar Kelimeler
4-methyl Morpholine, Anticancer Effect, Barbituric Acid, CoMFA Study, Eight-membered Intramolecular H-bond, Negative Charge-assisted H-bonds, Resonance-assisted H-bonds
Kaynak
Journal of the Chinese Chemical Society
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
67
Sayı
9
