Antibacterial, antioxidant, and angiotensin-I converting enzyme inhibition effects of margotia gummifera extracts rich in phenolic compounds

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dc.contributor.authorBouchekrit, Moufida
dc.contributor.authorLaouer, Hocine
dc.contributor.authorÇakmak, Yavuz Selim
dc.contributor.authorHajji, Mohamed
dc.contributor.authorBoutellaa, Saber
dc.contributor.authorNasri, Moncef
dc.contributor.authorAkkal, Salah
dc.date.accessioned2022-05-17T04:44:15Z
dc.date.available2022-05-17T04:44:15Z
dc.date.issued2022
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractAromatic and medicinal plants have been used to substitute synthetic drugs with natural bioactive products. Objective: The current investigation was conducted to evaluate phenol and flavonoid contents, antibacterial, antioxidant, and anti-hypertensive potentials of three extracts of Margotia gummifera aerial parts. Methods: The antibacterial effect was assessed using the wells agar diffusion method against 11 strains. The antioxidant effect was evaluated using different methods, 2, 2-diphenyl-1-picrylhy-drazyl, total antioxidant capacity, ferric reducing ability power, cupric reducing antioxidant capaci-ty, and ?-carotene/linoleic acid bleaching assay. The anti-hypertensive activity was performed using hippuryl-histidyl-leucine substrates. Results: The highest yield, i.e., 19.801%, was obtained by the hydro-methanolic extract. However, ethyl acetate extract seemed to be rich in phenolic and flavonoid compounds compared to other ex-tracts, i.e., 822.14±69.10 mg GAE g-1 ext. and 117.28±1.80 mg RE g-1 ext., respectively. The high free radical scavenging activity was mentioned in ethyl acetate extract with IC50 of 48.820±1.25 ?g/ml. The same extract showed better antioxidant activity in all tested procedures. In antibacterial activity, the hydro-methanolic extract exhibited moderate effect against all tested bacteria except Salmonella enterica and Enterococcus faecalis which gave 18±2.0 and 16±1.0 mm of inhibition, whereas it seemed to be inactive towards two Gram-negative bacteria. Concerning anti-hyperten-sive activity, all extracts can inhibit the Angiotensin-I Converting Enzyme, but the potential effect was given by hydro-methanolic and aqueous extracts, 97.75% and 96.65%, respectively. Conclusion: It can be stated that the bioactive compounds of Margotia gummifera extracts had different biological activities, which confirm their therapeutic uses in traditional medicine.
dc.identifier.doi10.2174/1573407217666210914090501
dc.identifier.endpage-en_US
dc.identifier.issn1573-4072
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.2174/1573407217666210914090501
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9390
dc.identifier.volume18en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofCurrent Bioactive Compounds
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAngiotensin-I
dc.subjectAnti-hypertensive Activity
dc.subjectAntibacterial Activity
dc.subjectAntioxidant Activity
dc.subjectMargotia Gummifera
dc.subjectPhenolic Compounds
dc.titleAntibacterial, antioxidant, and angiotensin-I converting enzyme inhibition effects of margotia gummifera extracts rich in phenolic compounds
dc.typeArticle

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