The Examination of Galectin-3 Levels in Children with Attention Deficit and Hyperactivity Disorder

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dc.authorid0000-0001-7909-9944
dc.authorid0000-0002-7504-5604
dc.contributor.authorArtık, Abdulbaki
dc.contributor.authorKocaman, Orhan
dc.contributor.authorKara, Halil
dc.date.accessioned2025-08-01T05:50:30Z
dc.date.available2025-08-01T05:50:30Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractThe etiopathogenesis of ADHD involves genetic, environmental, psychological, and brain structural vari- ables. Inflammation is one ADHD etiology study field. Galectin-3 may enhance inflammation by inhibiting the anti- inflammatory cytokine interleukin-10 (IL-10). This study examined the link between blood galectin-3 concentrations and ADHD severity and levels in children with ADHD. Methods: The clinic treated 34 first-time ADHD patients aged 5.2-14.1. Non-psychotropic first-time diagnoses were chosen. Patients were compared to 21 age- and gender-matched healthy controls. After a paediatrician exam, a psychi- atrist screens healthy controls for mental illness using the Schedule for Mood Disorders and Schizophrenia in School- Age Children, Now and Lifetime Version-DSM-5 (K-SADS-PL-DSM-5). Conners' Parent Rating Scale (CPRS) and Conners' Teacher Rating Scale( CTRS) were used for diagnosis by a child and adolescent psychiatrist. Results: Mean serum galectin-3 levels were compared between ADHD group and control groups. Serum galectin-3 level was 428.6 (SD±194.4) in the ADHD group and 183.7 ng/ml (SD±49.6) in the control group. ADHD group is found to have statistically significantly higher galectin-3 concentrations when compared to the control group (z=-5.15, p<.001). Conclusion: In our study, it was found that serum galectin-3 levels were higher in children with ADHD and there was a significant correlation between ADHD severity and serum galectin-3 levels. Based on these findings, it is thought that galectin-3 may be associated with the etiopathogenesis of ADHD.
dc.identifier.doi10.14744/ejmi.2023.18929
dc.identifier.endpage418
dc.identifier.issn2602-3164
dc.identifier.issue4
dc.identifier.startpage414
dc.identifier.urihttps://dx.doi.org/ 10.14744/ejmi.2023.18929
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13713
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKara, Halil
dc.institutionauthorid0000-0002-6128-0136
dc.language.isoen
dc.publisherKare Yayıncılık
dc.relation.ispartofEurasian Journal of Medical Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInflammation
dc.subjectADHD
dc.subjectGalectin-3 Levels
dc.titleThe Examination of Galectin-3 Levels in Children with Attention Deficit and Hyperactivity Disorder
dc.typeArticle

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