Medicinal applications, chemical compositions, and biological effects of an algerian ocimum basilicum L.var genovese; with the conversion of experimental doses to humans

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dc.authorid0000-0002-0533-4865
dc.contributor.authorFedoul, Firdaous Faiza
dc.contributor.authorMeddah, Boumediene
dc.contributor.authorLarouci, Mohammed
dc.contributor.authorTouil, Aicha Tir
dc.contributor.authorMerazi, Yahya
dc.contributor.authorBekhti, Nabila
dc.contributor.authorPiras, Alessandra
dc.contributor.authorFalconieri, Danilo
dc.contributor.authorÇakmak, Yavuz Selim
dc.date.accessioned2022-08-09T10:46:50Z
dc.date.available2022-08-09T10:46:50Z
dc.date.issued2022
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThis paper aims to analyze the medicinal uses of Ocimum basilicum L.var Genovese (basil) in western Algeria and its effectiveness. Materials and Methods: For the experiments, 154 structured questionnaires were collected to list the medicinal uses of basil. The essential oil of O. basilicum (EOB) obtained by hydro-distillation was analyzed by the GC/MS. The ethanolic and aqueous extracts (EEB and AEB) were analyzed by HPLC. The antioxidant activity was measured by DPPH assays and the antimicrobial activity was measured against fiv e microbes. For the in vivo study, Swiss albinos mice were used to determine the toxicity using Lorke’s method. The anti-inflammatory activity was determined using the Carrageenan method. The experimental doses were converted from mice to humans using the Km factor. Results: The ethnobotanical study indicates that local people use basil to treat diseases and health problems (50% for i nflammation and 38.11% for microbial diseases). The results also show that EOB contains 41.3% linalool, whereas ethanolic extract contains benzoic a cid (50.86 mg/g). The IC50 value is 556, 878.7, and 962.3 µg/ml for EOB, EEB, and AEB, respectively. The EOB and AEB inhibit the positive Gram bacteria and yeast; the EEA inhibits the negative Gram. The LD50 is 400, 470, and >5000 mg/kg for AEB, EOB, and EEB respectively. The results of the anti-inflammatory test highlight 76.33, 71.0, and 60.43% inhibition of edema at a 100 mg/kg dose for EOB, AEB, and EEB, respectively. Conclusions: The Algerian basil can be considered as an antioxidant, antimicrobial and anti-inflammatory.
dc.identifier.doi10.30491/jabr.2021.290237.1401
dc.identifier.endpage683en_US
dc.identifier.issn2322-1186
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage671en_US
dc.identifier.urihttps:/dx.doi.org/10.30491/jabr.2021.290237.1401
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9642
dc.identifier.volume9en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBaqiyatallah University of Medical Sciences
dc.relation.ispartofJournal of Applied Biotechnology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnti-inflammatory
dc.subjectAntimicrobial
dc.subjectBasil
dc.subjectEthnobotany
dc.subjectHuman Dose
dc.subjectToxicity
dc.titleMedicinal applications, chemical compositions, and biological effects of an algerian ocimum basilicum L.var genovese; with the conversion of experimental doses to humans
dc.typeArticle

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