Role of glial fibrillary acidic protein (GFAP) and neurofilament (NF) expression in the pathophysiology of canine distemper encephalomyelitis

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dc.authorid0000-0002-8075-9564
dc.authorid0000-0003-2457-3367
dc.authorid0000-0002-6985-3197
dc.contributor.authorDinçel, Güngör Çağdaş
dc.contributor.authorYavuz, Orhan
dc.contributor.authorYıldırım, Serkan
dc.date.accessioned2024-03-28T05:55:13Z
dc.date.available2024-03-28T05:55:13Z
dc.date.issued2023
dc.departmentEskil Meslek Yüksekokulu
dc.description.abstractCanine distemper virus (CDV), a member of the genus Morbillivirus of the family Paramyxoviridae, is the causative agent of canine distemper, a fatal and highly contagious disease that affects dogs and other carnivores. This study aimed to investigate whether there is a correlation between glial fibrillary acidic protein (GFAP) and neurofilament (NF) expression in canine distemper encephalomyelitis (CDE) and the severe neuropathology that occurs. Materials and Methods: GFAP and NF expression levels in the brain tissue of 13 dogs diagnosed with CDE were investigated by immunohistochemical method. Results: The results of the study revealed that GFAP (P < 0.005) and NF (P < 0.005) expression levels in brain tissue were significantly increased in CDV-infected dogs compared to healthy, uninfected dogs. GFAP expression was mainly observed in endothelial cells and astrocytes, whereas NF expression was mainly found in neurons. In addition, it was found that the expression of both GFAP and NF was more pronounced in the areas with the most severe neuropathological findings. Conclusions: This study demonstrated pathological astrocyte reactivation and neuronal degeneration at the molecular level. These findings provide information about the stage of the disease. This study clearly demonstrated that detailed information about the prognosis of the disease can be obtained from GFAP and NF expression. Since GFAP/NF levels provide information about the severity of the disease, they can be used clinically. Therefore, further research into the involvement of GFAP and NF expression in the pathophysiology of CDE has great potential to improve our understanding of this complex neurological disorder.
dc.identifier.doi10.47748/tjvr.1296010
dc.identifier.endpage113en_US
dc.identifier.issn2602-3695
dc.identifier.issue2en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps:/dx.doi.org10.47748/tjvr.1296010
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11575
dc.identifier.volume7en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherEbubekir CEYLAN
dc.relation.ispartofTurkish Journal of Veterinary Research (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectCanine Distemper
dc.subjectGFAP
dc.subjectNF
dc.subjectNeuropathology
dc.subjectEncephalomyelitis
dc.titleRole of glial fibrillary acidic protein (GFAP) and neurofilament (NF) expression in the pathophysiology of canine distemper encephalomyelitis
dc.typeArticle

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