Comparative Evaluation of Argyrophilic Nucleolar Organizer Regions Parameters in Benign and Malignant Breast Tumors

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dc.contributor.authorKöksal, Mehmet
dc.contributor.authorDoğan, Serap
dc.contributor.authorEroz, Recep
dc.contributor.authorÖztürk, Figen
dc.contributor.authorÖztürk, Ahmet
dc.contributor.authorCücer, Nurhan
dc.date.accessioned2023-10-19T10:52:08Z
dc.date.available2023-10-19T10:52:08Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractThe aim of the paper was to evaluate the AgNOR parameters for the discrimination of benign from malignant breast tumors via a new approach -the total AgNOR area/nuclear area (TAA/NA). Material and methods. Three groups, consisting of control (n = 14), benign (n = 18) and malignant (n = 28) participants were included in the study. The AgNOR staining technique was performed and both mean AgNOR number and TAA/NA ratio were evaluated.Results. While the differences between the control and patient groups were statistically significant for AgNOR number (p < 0.001), it was not significant between the malignant group and the benign group for mean AgNOR number (p > 0.05). For the ratio of TAA/NA, the differences between the control and benign group (p < 0.001), control and malignant group (p < 0.001), and malignant and benign patient groups were significant. (p < 0.05).Conclusion. We consider that the evaluation of the TAA/NA rate, when compared with the AgNOR number, can be more sensitive and useful tool for distinguishing benign from the malignant breast lesions.
dc.identifier.doi10.5937/afmnai40-35516
dc.identifier.endpage101en_US
dc.identifier.issn0351-6083
dc.identifier.issn2217-2521
dc.identifier.issue1en_US
dc.identifier.startpage90en_US
dc.identifier.urihttps:/dx.doi.org10.5937/afmnai40-35516
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11187
dc.identifier.volume40en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherUniversity of Nis Faculty of Medicine
dc.relation.ispartofActa Facultatis Medicae Naissensis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreastbreast
dc.subjectBreast
dc.subjectBreast Cancer
dc.subjectNucleolar Organizing
dc.subjectNucleolar Organizing Regions
dc.subjectAgNOR
dc.titleComparative Evaluation of Argyrophilic Nucleolar Organizer Regions Parameters in Benign and Malignant Breast Tumors
dc.typeArticle

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