Pathological and biochemical investigation of the effects of L-carnitine and gemfibrozil on peroxisome proliferator activated receptors (PPARS) and lipidosis in rabbits on a high-fat diet

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dc.authorid0000-0001-9839-7533
dc.authorid0000-0003-0004-7485
dc.authorid0000-0002-3064-6633
dc.authorid0000-0003-0408-534X
dc.authorid0000-0002-8004-7364
dc.authorid0000-0003-0287-4521
dc.authorid0000-0002-1040-3255
dc.authorid0000-0003-2461-5598
dc.authorid0000-0003-1879-8180
dc.contributor.authorÇıtıl, Mehmet
dc.contributor.authorTunca, Recai
dc.contributor.authorUzlu, Erdoğan
dc.contributor.authorKarapehlivan, Mahmut
dc.contributor.authorAdalı, Yasemen
dc.contributor.authorYapar, Kürşad
dc.contributor.authorEroğlu, Hüseyin Avni
dc.contributor.authorErkılıç, Ekin Emre
dc.contributor.authorMakav, Mustafa
dc.contributor.authorErdoğan, Hidayet Metin
dc.date.accessioned2025-09-09T08:29:50Z
dc.date.available2025-09-09T08:29:50Z
dc.date.issued2022
dc.departmentVeteriner Fakültesi
dc.description.abstractObesity and fatty liver is a worldwide health problem in human with detrimental consequences where many investigations are undertaken to overcome this problem. In this study, gemfibrozil and L-carnitine were evaluated in prevention of obesity and lipidosis. The study involved 56 New-Zealand Albino rabbits, divided into 8 equal groups (n=7). The groups were as follow; group I (normal diet), II (normal diet +gemfibrozil), III (normal diet+L-carnitine) and IV (normal diet+gemfibrozil+L- carnitine), V (high fat diet), VI (high fat diet+gemfibrozil), VII (high fat diet+L- carnitine) and VIII (high fat diet+gemfibrozil+L-carnitine). Animals were blood sampled and wieght weekly during the experiment and at the end of the experiment for determination of biochemical parameters (glucose, total lipid). All rabbits were euthanised for histopathological examination and for distrubition of peroxisome proliferator activated receptors (PPARs) in tissues by immunohystochemistry. Gemfibrozil and L-carnitin treatment in rabbits given high fat diet resulted in statistically significant decrease in total lipid when compared to those only received high fat diet. Beta oxidation of high fat diet group was significantly higher than that of groups additionally received gemfibrozil and L-carnitine. Immunohistochemistry revealed an increase in PPAR, PPAR-α and β but not PPAR-γ expression in high fat diet group. On the contrary, L-carnitin administration had no effect on tissue PPAR expression. PPAR-α expression differed between groups received gemfibrozil and high fat diet and those did not. The most marked macroscopy finding was abdominal fat increase in high fat diet group (group V). On the other hand gemfibrozil administration resulted in significant abdominal fat decrease. Furthermore decreased abdominal fat was marked in gemfibrozil and L-carnitine given animals (group VIII) when compared to other groups. In conclusion, gemfibrozil and L-carnitine administration alleviated abdominal and hepatic fattening. Gemfibrozil also caused a significant increase in PPAR-α expression in the liver. It may be of use in avoiding abdominal fat (obesity) due to high fat diet by use of gemfibrozil, a synthetic PPAR-a ligand, and L-carnitine.
dc.identifier.doi10.31797/vetbio.1136444
dc.identifier.endpage360
dc.identifier.issn2548-1150
dc.identifier.issue3
dc.identifier.startpage346
dc.identifier.urihttps://doi.org/10.31797/vetbio.1136444
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14221
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorErdoğan, Hidayet Metin
dc.institutionauthorid0000-0003-1261-4352
dc.language.isoen
dc.publisherİlker ÇAMKERTEN
dc.relation.ispartofJournal of Advances in VetBio Science and Techniques
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectL-carnitine
dc.subjectObesity
dc.subjectPPARs
dc.subjectRabbits
dc.subjectGemfibrozil
dc.titlePathological and biochemical investigation of the effects of L-carnitine and gemfibrozil on peroxisome proliferator activated receptors (PPARS) and lipidosis in rabbits on a high-fat diet
dc.typeArticle

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