C-Reactive protein-to-Albumin ratio: A novel inflammatory marker and disease activity sign in early rheumatoid arthritis

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dc.contributor.authorÖnder, Mustafa Erkut
dc.contributor.authorOruçoğlu, Nurdan
dc.contributor.author(Omar, Fırat
dc.contributor.authorCanataroğlu, Abdullah
dc.date.accessioned2022-01-28T11:01:17Z
dc.date.available2022-01-28T11:01:17Z
dc.date.issued2021
dc.departmentTıp Fakültesi
dc.description.abstractObjective A novel inflammation-based score, C-reactive protein (CRP)-to-albumin ratio (CAR), has been shown to have an association with the inflammatory status in several diseases. We aimed to analyse the association between CAR and disease activity in patients with early rheumatoid arthritis (RA) and to determine the cut-off value of CAR in early and established RA. Methods A total of 177 patients with RA and 111 age and gender-matched healthy controls were included in this study. Cases with a disease duration of less than 1 year were classified as early RA. Serum albumin, CRP, erythrocyte sedimentation rate (ESR), Disease Activity Score-28 (DAS-28-ESR), Clinical Disease Activity Index (CDAI) and Health Assessment Questionnaire (HAQ) scores were recorded. Results CAR was 2.44 (0.21–30.83) in the RA group and 0.45 (0.21–10.47) in the control group (p<0.001). Eighty-seven (49.15%) of the RA cases were classified as early RA. The analyses indicated that the ESR, CRP and CAR values were higher in patients with early RA than in those with established RA and controls. CAR was correlated with albumin, CRP, ESH, DAS-28 and HAQ scores in both early RA and established RA groups. The receiver operating characteristic curves revealed a CAR cut-off value of 2.67 (80% sensitivity and 85% specificity) and 1.63 (77% sensitivity and 72% specificity) for the prediction of early and established RA, respectively. Conclusion CAR, a formulated ratio, has been described as a predictor for disease activity in patients with early RA as well as in those with established RA. However, CAR has higher sensitivity and specificity for early RA than for established RA.
dc.identifier.doi10.1055/a-1653-1172
dc.identifier.endpage-en_US
dc.identifier.issn0341-051X
dc.identifier.issn1438-9940
dc.identifier.issue-en_US
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1055/a-1653-1172
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9170
dc.identifier.volume-en_US
dc.identifier.wosWOS:000717774300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherGeorg Thieme Verlag
dc.relation.ispartofAktuelle Rheumatologie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectC-reactive Protein
dc.subjectAlbumin
dc.subjectInflammation
dc.subjectRheumatoid Arthritis
dc.subjectC-reaktives Protein
dc.subjectEntzundung
dc.subjectRheumatoide Arthritis
dc.titleC-Reactive protein-to-Albumin ratio: A novel inflammatory marker and disease activity sign in early rheumatoid arthritis
dc.typeArticle

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