A study of cancer-related genes: Prevalence of polymorphic GSTT1 and GSTM1 deletions in Turkey

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dc.contributor.authorKaraca, Şefayet
dc.contributor.authorKaraca, Mehmet
dc.contributor.authorKaymaz, Ayşe
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:23:03Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:23:03Z
dc.date.issued2013
dc.departmentSağlık Bilimleri Fakültesi
dc.description.abstractThe major burden of cancer in the general population is results from the complex interactions of multiple genetic and environmental factors over time. Population based studies support the involvement of GSTM1 and GSTT1 deletion in susceptibility to commonly occurring forms of cancer. The aim of this study was to determine frequency of GSTM1 and GSTT1 deletion variants in Turkish population. Deletion polymorphisms were screened in a collection of samples n=507 for GSTM1 and n=464 for GSTT1. After isolation of DNAs from whole blood, sequences of interest were amplified and then analyzed by electrophoretic methods in the presence of positive and negative controls. Allele frequencies were detected as 52% for GSTM1 and 24% for GSTT1 deletion polymorphisms. The obtained frequencies were consistent with the values that reported for different populations. Cancer is a disease of the genome and identification of the genetic characteristics of healthy individuals is important in determining of current risks, developing of preventive health care models and medical follow-up programs to reducing risk of diseases. However, during the treatment process it allows the selection of optimal therapy.
dc.identifier.endpage3en_US
dc.identifier.issn1307-1130
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2694
dc.identifier.volume7en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofJournal of Applied Biological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCancer genetics
dc.subjectGSTM1 and GSTT1 deletions
dc.titleA study of cancer-related genes: Prevalence of polymorphic GSTT1 and GSTM1 deletions in Turkey
dc.typeArticle

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