Determination of serum perfluorooctanoic acid and perfluorooctanesulfonic acid levels with different stages of chronic kidney disease

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dc.contributor.authorErdal, Hüseyin
dc.contributor.authorSungur, Sana
dc.contributor.authorKöroğlu, Muaz
dc.contributor.authorTurgut, Faruk
dc.date.accessioned2025-10-10T13:31:57Z
dc.date.available2025-10-10T13:31:57Z
dc.date.issued2021
dc.departmentTıp Fakültesi
dc.description.abstractThe aim of this study is to investigate the perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) levels in patients with different stages of chronic kidney disease (CKD). Sixty-one CKD stage 1-4 patients who applied to the nephrology outpatient clinic were recruited. A control group consisting of 26 age- and sex-matched healthy controls were also included in the study. Concentrations of PFOA and PFOS were determined by comparing their peak areas with their standard curves. All samples were analyzed three times. The average values of blank samples were subtracted from the detected PFOA and PFOS values. PFOA and PFOS levels were significantly higher in CKD group than the controls (11.4 ± 7.47, 0.45 ± 0.55; 0.13 ± 0. 17, 0.19 ± 0.4 ng/mL, respectively) (P = 0.001). Hemoglobin, serum albumin, and estimated glomerular filtration rate (eGFR) levels were significantly lower and potassium and uric acid levels were higher in the CKD group than the controls. PFOA and PFOS levels were significantly higher in all stages of CKD patients than healthy controls. However, there was no correlation between eGFR, and PFOS and PFOA. We have demonstrated significantly increased PFOA and PFOS concentrations in different stages of CKD patients. We could not find an association between eGFR, age, and serum PFOS and PFOA concentrations.
dc.identifier.doi10.4103/1319-2442.352427
dc.identifier.endpage1670
dc.identifier.issn13192442
dc.identifier.issue6
dc.identifier.pmid35946279
dc.identifier.scopus2-s2.0-85135725798
dc.identifier.scopusqualityQ3
dc.identifier.startpage1664
dc.identifier.urihttps://doi.org/10.4103/1319-2442.352427
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14695
dc.identifier.volume32
dc.indekslendigikaynakScopus
dc.institutionauthorErdal, Hüseyin
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofSaudi Journal of Kidney Diseases and Transplantation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlkanesulfonic Acids
dc.subjectCaprylates
dc.subjectFluorocarbons
dc.subjectHumans
dc.subjectRenal Insufficiency
dc.subjectChronic
dc.titleDetermination of serum perfluorooctanoic acid and perfluorooctanesulfonic acid levels with different stages of chronic kidney disease
dc.typeArticle

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