Effect of paclitaxel and resveratrol on New Zealand rabbit semen

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dc.contributor.authorÖztürk, Caner
dc.contributor.authorAtaman, Mehmet Bozkurt
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:25:44Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:25:44Z
dc.date.issued2018
dc.departmentVeteriner Fakültesi
dc.description.abstractObjective: To examine the effects of paclitaxel and resveratrol on rabbit semen. Methods: This study consisted of four groups: control group (40 mL saline), paclitaxel group (5 mg/kg paclitaxel), resveratrol group (4 mg/kg resveratrol) and paclitaxel+resveratrol group (5 mg/kg paclitaxel+4 mg/kg resveratrol). Administrations were i.v. (in 40 mL saline) and continued 8 weeks. Sperm motility was evaluated using phase-contrast microscopy. Mitochondrial activity, membrane and acrosome integrity were performed by fluorescence staining. Lipid peroxidation, total glutathione and antioxidant potential levels were determined by spectrophotometry. Results: Paclitaxel decreased the sperm motility and fluorescence staining results compared to the control (P<0.05). The paclitaxel and resveratrol group showed better results of the same parameters compared to the paclitaxel group (P<0.05). No significant difference was observed in lipid peroxidation, total glutathione, antioxidant potential and fertility results (P>0.05). Results of this study showed that paclitaxel decreased semen parameters and resveratrol had a protective effect on these parameters. Conclusions: Paclitaxel has negative effects on spermatological indicators and biochemical assays, while resveratrol prevents these negative effects of paclitaxel.
dc.identifier.doi10.4103/2305-0500.246345
dc.identifier.endpage269en_US
dc.identifier.issn2305-0500
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage266en_US
dc.identifier.urihttps://dx.doi.org/10.4103/2305-0500.246345
dc.identifier.urihttps://hdl.handle.net/20.500.12451/3084
dc.identifier.volume7en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofAsian Pacific Journal of Reproduction
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnticancer Drug
dc.subjectAntioxidant
dc.subjectOxidative Stress
dc.subjectSperm Parameters
dc.titleEffect of paclitaxel and resveratrol on New Zealand rabbit semen
dc.typeArticle

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