Investigation of antioxidant and anzyme inhibition Activities and phenolic Compound of medicago rigidula (L.) All

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dc.authoridZengin, Gokhan -- 0000-0001-6548-7823;
dc.contributor.authorÇakmak, Yavuz Selim
dc.contributor.authorZengin, Gökhan
dc.contributor.authorEskin, Bülent
dc.contributor.authorYıldırım, Kevser
dc.contributor.authorTopal, Müge
dc.contributor.authorAydın, Gözde Hatun
dc.contributor.authorÜnlü, Emre
dc.contributor.authorBaydemir, Merve
dc.contributor.authorErten, Kübra
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:15:27Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:15:27Z
dc.date.issued2017
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe study focused on evaluating of antioxidant capacity, phenolic compounds and enzyme inhibition activity of methanolic extract Medicago rigidula. Antioxidant activity was evaluated using different assays including 2,2-diphenyl-1-pikrylhydrazyl (DPPH), ferric ion reducing antioxidant power (FRAP), cupric ion reducing antioxidant capacity (CUPRAC) and total antioxidant capacity (phosphomolybdenum) test. Total phenolic and flavonoit contents were also determined. Enzyme inhibition activities were examined against anticholinesterase, tyrosinase, alpha-amylase and alpha-glucosidase. Phenolic content of M. rigidula included catechin, cinnamic, chlorogenic, gallic and syringic acids. Free radical scavenging activity of methanol extract was 20.30% at 1 mg/mL concentration. In phosphomolybdenum and FRAP tests were found 167.27 mg AAE/g and 67.01 mg TE/g, respectively. Total phenolic and flavonoid contents were determined as 79.61 mg GAE/g and 27.38 mu g QE/g, respectively. The results showed that M. rigidula has a good source of antioxidants and enzyme inhibition capacity. Thus, it can be used as raw material in food and pharmaceutical industry.
dc.identifier.doi10.12991/marupj.311816
dc.identifier.endpage529en_US
dc.identifier.issn1309-0801
dc.identifier.issue3en_US
dc.identifier.startpage522en_US
dc.identifier.urihttps://doi.org/10.12991/marupj.311816
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4385
dc.identifier.volume21en_US
dc.identifier.wosWOS:000417368400013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isotr
dc.publisherMarmara University, Fac, Pharmacy
dc.relation.ispartofMarmara Pharmaceutical Journa
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChemical Composition
dc.subjectBioactivity
dc.subjectHPLC Analysis
dc.subjectFabaceae
dc.titleInvestigation of antioxidant and anzyme inhibition Activities and phenolic Compound of medicago rigidula (L.) All
dc.typeArticle

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