Seven-coordinated cobalt(II) complexes with 2,6-diacetylpyridine bis(4-hydroxybenzoylhydrazone): synthesis, characterisation, DNA binding and cleavage properties

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dc.authoridOzcelik, Nefise -- 0000-0002-6972-1071; Gokce, Cansu -- 0000-0002-6834-4841
dc.contributor.authorGüp, Ramazan
dc.contributor.authorGökçe, Cansu
dc.contributor.authorDilek Özçelik, Nefise
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:30:20Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:30:20Z
dc.date.issued2015
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractSynthesis and characterisation of three seven-coordinated cobalt(II) complexes of 2,6-diacetylpyridine bis(4-hydroxybenzoylhydrazone) (H4L) ligand, [Co(H2L)(H2O)(2)] (1), [Co(H4L)(N-3)(2)] (2) and [Co(H4L)(NCS)(2)] (3) are described. The structures of the complexes were characterised by elemental analysis, IR, UV-vis and magnetic susceptibility measurement. The molecular structure of the [Co(H4L)(NCS)(2)] (3) was also determined by X-ray crystallography. Single crystal X-ray revealed that the Co(II) complex (3) has a pentagonal-bipyramidal coordination geometry, with pentadentate N3O2 ligand in the equatorial plane of the bipyramid and two isothiocyanato groups in the axial area. Interaction of the cobalt(II) complexes with CT-DNA was investigated by absorption titration method and viscosity measurements. Cleavage activity of the complexes with pBR 322 plasmid DNA was evaluated by agarose gel electrophoresis in presence and absence of an oxidative agent, and the mechanism of DNA cleavage was investigated. The results suggest that the cobalt(II) complexes bind effectively and they exhibit nuclease activity, which has strong dependence on the concentration of complex and reaction time, both in presence and absence of hydrogen peroxide.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK] [TBAG-112T315]
dc.description.sponsorshipThis work was funded by the Scientific and Technological Research Council of Turkey [TUBITAK, TBAG-112T315].
dc.identifier.doi10.1080/10610278.2015.1051978
dc.identifier.endpage641en_US
dc.identifier.issn1061-0278
dc.identifier.issn1029-0478
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage629en_US
dc.identifier.urihttps://doi.org/10.1080/10610278.2015.1051978
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6264
dc.identifier.volume27en_US
dc.identifier.wosWOS:000362878300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofSUPRAMOLECULAR CHEMISTRY
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subject2
dc.subject6-diacetylpyridine
dc.subjectAroylhydrazone
dc.subjectCobalt(II) Complex
dc.subjectDNA Binding
dc.subjectNuclease Activity
dc.titleSeven-coordinated cobalt(II) complexes with 2,6-diacetylpyridine bis(4-hydroxybenzoylhydrazone): synthesis, characterisation, DNA binding and cleavage properties
dc.typeArticle

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