Esculetin improves chemotherapy-induced impaired anxiety-depression-like behaviors and learning activity

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dc.authorid0000-0003-3780-4021
dc.authorid0000-0003-4167-2623
dc.contributor.authorTaşpınar, Filiz
dc.contributor.authorÖz, Mehmet
dc.date.accessioned2025-04-11T07:23:52Z
dc.date.available2025-04-11T07:23:52Z
dc.date.issued2024
dc.departmentTıp Fakültesi
dc.description.abstractThis study aimed to assess the neuroprotective effectiveness of esculetin in preventing cognitive and emotional impairments caused by chemotherapy. In order to cause cognitive impairment in mice, a single intraperitoneal dosage of m ethotrexate (Mtx) at a concentration of 40 mg/kg was administered. Esculetin (Elt) was administered orally at a daily dose of 40 mg/kg one week before the Mtx injection. The locomotor activity was assessed using the Pole (PT) and open field (OF) tests. Anxiety-like behaviors were evaluated using the open field and elevated plus maze (EPM) tests. Depression-like behaviors were assessed using the tail suspension test (TST). Learning and memory activity was evaluated using the novel object recognition test (NO R). Mtx did not affect the locomotor activities of mice, but anxiety-like behaviors were found to be increased in the OF and EPM tests. It also increased the duration of immobility in the TST, causing a negative discrimination index in the NOR. Elt alleviated anxiety and depression-like behaviors generated by Mtx and enhanced cognitive function related to learning and memory. Elt significantly increased the time spent in the center zone in the OF test, the total time spent in the open arms in the EPM, and the immobility time in the TST. Moreover, it improved the discrimination index in NOR, which had been reduced by Mtx. Administering a single dose of Mtx at 40 mg/kg resulted in increased anxiety and depression-like behaviors, impaired learning and memory functions. Besides that, supplementing with Elt significantly mitigated the neurological impairments caused by Mtx.
dc.identifier.doi10.5505/ejm.2024.85353
dc.identifier.endpage530
dc.identifier.issn13010883
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85208413144
dc.identifier.scopusqualityQ4
dc.identifier.startpage524
dc.identifier.urihttps://dx.doi.org/10.5505/ejm.2024.85353
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13010
dc.identifier.volume29
dc.indekslendigikaynakScopus
dc.institutionauthorTaşpınar, Filiz
dc.institutionauthorÖz, Mehmet
dc.institutionauthorid0000-0003-3780-4021
dc.institutionauthorid0000-0003-4167-2623
dc.language.isoen
dc.publisherYuzuncu Yil Universitesi Tip Fakultesi
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnxiety
dc.subjectDepression
dc.subjectEsculetin
dc.subjectLearning
dc.subjectMethotrexate
dc.titleEsculetin improves chemotherapy-induced impaired anxiety-depression-like behaviors and learning activity
dc.typeArticle

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