InvestIgatIon of cyto-toxIcIty of an InnovatIve BIofactor Mta product In dIfferent huMan cells: a pIlot study

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dc.authorid0000-0002-8837-3754
dc.authorid0000-0002-2996-7632
dc.authorid0000-0002-6311-385X
dc.authorid0000-0003-3780-4021
dc.authorid0000-0003-4245-3780
dc.authorid0000-0001-5439-6598
dc.authorid0000-0002-2689-5960
dc.contributor.authorAkyol, Gülter Devrim
dc.contributor.authorKolcu, Mukadder İnci Başer
dc.contributor.authorAlpaslan, Nazlı Zeynep
dc.contributor.authorTaşpınar, Filiz
dc.contributor.authorMızrak, Rodi Yusuf
dc.contributor.authorKeskin Tunç, Serap
dc.contributor.authorİnanç, Bülend
dc.date.accessioned2023-10-10T06:28:32Z
dc.date.available2023-10-10T06:28:32Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractMineral trioxide aggregate (MTA) is one of the most popular and convenient material among current endodontic materials. In addition to MTA advantages, there are also features that need to be improved. Color stability and consistency are notorious concerns in MTA, and materials need improvement regarding theses aspects. There are companies, which work on these contents. Objectives: The aim of this study was to investigate the cyto-toxicity of Biodentine, Angelus MTA, BIOfactor MTA on 3T3L-1 fibroblast, and Saos-2 osteosarcoma cell lines with different dilution of all products. Material and methods: 3T3-1 fibroblast was applied to stimulate pulp cells in cell viability test. In order to generate an osteoblastic cell-like model, only Saos-2 cells were used. MTT test was utilized to measure cell cytotoxicity in different dilution of all MTA products. SPSS package program was applied to perform Kruskal-Wallis, one-way ANOVA and two-way ANOVA tests. Results: According to results, while Biodentine, Angelus MTA and BIOfactor MTA showed cyto-toxic effects in 1: 1 and 1: 2 dilutions, they were not cyto-toxic in 1: 4 and 1: 8 dilutions. Conclusions: MTA products have similar cyto-toxicity. BIOfactor MTA has a cyto-toxic effect as other similar products.
dc.identifier.doi10.5114/jos.2023.128770
dc.identifier.endpage76en_US
dc.identifier.issn0011-4553
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage71en_US
dc.identifier.urihttps:/dx.doi.org10.5114/jos.2023.128770
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11112
dc.identifier.volume76en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTermedia Publishing House Ltd.
dc.relation.ispartofJournal of Stomatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAngelus MTA
dc.subjectBiodentine
dc.subjectBIOfactor MTA
dc.subjectCyto-toxicity
dc.subjectMTT Assay
dc.titleInvestIgatIon of cyto-toxIcIty of an InnovatIve BIofactor Mta product In dIfferent huMan cells: a pIlot study
dc.typeArticle

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