Argyrophilic nucleolar organizer regions as a promising biomarker for the detection of brain hypoxia levels caused by different doses of carbon monoxide poisoning

Basit Öğe Kaydı
dc.contributor.authorYeşildağ, Kerim
dc.contributor.authorKokulu, Kamil
dc.contributor.authorMutlu, Hüseyin
dc.contributor.authorEröz, Recep
dc.contributor.authorTaha Sert, Ekrem
dc.contributor.authorSarıtaş, Ayhan
dc.date.accessioned2022-01-27T06:01:53Z
dc.date.available2022-01-27T06:01:53Z
dc.date.issued2021
dc.departmentTıp Fakültesi
dc.description.abstractThe purpose of the study is to investigate whether there is any relationship between mean argyrophilic nucleolar organizing regions (AgNOR) number and total AgNOR area/total nuclear area (TAA/TNA) ratio and the levels of brain hypoxia after exposure to different acute doses of carbon monoxide (CO) gas. Methods: Each experimental group was exposed to CO gas (concentrations of 1,000, 3,000 and 5,000 ppm). Then, the rats were anesthetized, and blood samples were taken from the right jugular vein for carboxyhemoglobin levels detection. The rats were sacrificed on seventh day. AgNOR staining was applied to brain tissues. TAA/TNA and mean AgNOR number were detected for each nucleus. Results: Significant differences were detected among the all groups for TAA/TNA ratio, mean AgNOR number and carboxyhemoglobin level. According to double comparison of groups, the differences between control and 1000ppm, control and 3000ppm, control and 5000ppm and 1000 and 5000ppm were significant for TAA/TNA ratio. When mean AgNOR number to be considered, significant differences were detected between control and 1000ppm, control and 3000ppm, control and 5000ppm and 1000 and 3000ppm. Conclusion: AgNOR proteins may be used for early detection of the duration, intensity and damage of brain injury caused by CO intoxication. Thus, effective treatment strategies for the prevention of hypoxic conditions may be developed.
dc.identifier.doi10.24875/GMM.21000273
dc.identifier.endpage637en_US
dc.identifier.issn0016-3813
dc.identifier.issue6en_US
dc.identifier.pmid35108251
dc.identifier.startpage630en_US
dc.identifier.urihttps:/dx.doi.org/10.24875/GMM.21000273
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9160
dc.identifier.volume157en_US
dc.identifier.wosWOS:000721682600010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherAcademia Nacional de Medicina de México
dc.relation.ispartofGaceta Médica de México
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectArgyrophilic Nucleolar Organizer Regions
dc.subjectBrain
dc.subjectCO Poisoning
dc.subjectNucleolar Organizer Regions
dc.subjectrDNA
dc.titleArgyrophilic nucleolar organizer regions as a promising biomarker for the detection of brain hypoxia levels caused by different doses of carbon monoxide poisoning
dc.typeArticle

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