Contribution to pharmacological valorisation of Algerian arctium minus (Hill) bernh. subsp. atlanticum (Pomel) maire; antioxidant and acetylcholinesterase inhibitory activities

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dc.contributor.authorGuettaf, Sofiane
dc.contributor.authorBenmerzoug, Abdelmoumen
dc.contributor.authorChawki, Bensouici
dc.contributor.authorÇakmak, Yavuz Selim
dc.contributor.authorDahamna, Saliha
dc.contributor.authorBaghiani, Abderrahmane
dc.contributor.authorHarzallah, Daoud
dc.date.accessioned2023-01-12T10:33:15Z
dc.date.available2023-01-12T10:33:15Z
dc.date.issued2022
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe traditional pharmacopoeia is full of potential resources for molecules with therapeutic effects involving the inhibition of enzymes linked to some diseases. Objective: This work aimed to test in vitro neuroprotective activity against Alzheimer's disease (AD) combined with the antioxidant effect of root extracts obtained by water, water/methanol, and ethyl acetate of the endemic Arctium minus. subsp. Atlanticum, a native of Algeria. Methods: The different extracts of the root of the studied plant were obtained by decoction or maceration. The inhibitory effect of acetyl/butyrylcholinesterase (AChE/BChE) was achieved by a colorimetric method. Similarly, the antioxidant activity was measured based on several mechanisms: 1, 1diphenyl-2-picryl-hydrazyl (DPPH) and galvinoxyl (GOR) radicals free scavenging assays, ?-carotene bleaching inhibition activity, and cupric ion reducing antioxidant capacity (CUPRAC). Results: In the various tests carried out, the ethyl acetate extract (EAE) possessed the most powerful antioxidant and anticholinesterase activities compared to the other samples. The IC50 and A0.5 values of DPPH, GOR, ?-carotene, CUPRAC, anti-AChE, and anti-BChE assays were 69.45±5.49, 28.87±0.18, 121.58±16.76, 37.41±1.59, 265±21, and 240±6.3 µg / mL, respectively. Likewise, a correlation could be deduced between the type of extract and the potent antioxidant/anticholinesterase potential. Conclusion: This work examines for the first time the anticholinesterase potential combined with the antioxidant effect of Algerian Arctium minus. subsp. atlanticum. This association between the two effects could be effective in the fight against AD, and therefore, the use of this natural resource may be possible in combating this aspect of neurodegeneration.
dc.identifier.doi10.2174/1573408018666220324101521
dc.identifier.endpage144en_US
dc.identifier.issn1573-4080
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage135en_US
dc.identifier.urihttps:/dx.doi.org/10.2174/1573408018666220324101521
dc.identifier.urihttps://hdl.handle.net/20.500.12451/9891
dc.identifier.volume18en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofCurrent Enzyme Inhibition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcetylcholinesterase Inhibitory Activities
dc.subjectAlzheimer’s Disease
dc.subjectAnticholinesterase
dc.subjectAntioxidant
dc.subjectArctium Minus
dc.subjectEnzyme Inhibition
dc.subjectPharmacological Valorisation
dc.titleContribution to pharmacological valorisation of Algerian arctium minus (Hill) bernh. subsp. atlanticum (Pomel) maire; antioxidant and acetylcholinesterase inhibitory activities
dc.typeArticle

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