Psödoeksfoliasyon sendromu ve antidepresan ilaç kullanımı
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Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Türk Oftalmoloji Derneği
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Psödoeksfoliasyon sendromu (PES) ile antidepresan ilaç kullanımı arasındaki ilişkiyi araştırmaktır.Gereç ve Yöntem: Eskişehir’de PES sıklığının saptanması amacıyla yapılan bir epidemiyolojik çalışma için Türkiye İstatistikKurumu tarafından randomize seçilen 2356 kişiden 2017’si çalışmaya katıldı. Muayene sırasında hekim tanılı sistemik hastalıklar veilaç kullanımının belirlenmesi amacıyla ayrıntılı bir anket uygulaması yapıldı.Bulgular: Çalışmaya katılan 2017 kişinin 8’i çeşitli sebeplerle (2 posterior sineşili, 2 kornea opasitesi,1 kooperasyon yetersizliği, 1tek gözlülük, 1 aktif adenoviral konjonktivit ve 1 dar açılı glokom öyküsü) çalışma dışı bırakıldı. Verileri analiz edilen 2009 kişiden100’ünde (%5) PES saptandı. Antidepresan ilaç kullanım sıklığı PES (-) glokomu olmayan grupta %1,1 (n=21), PES (+) glokomuolmayan grupta ise %4,1 (n=3) olarak tespit edildi. Her iki grup arasındaki fark istatistiksel olarak anlamlı idi (p=0,024). Ayrıcaantihipertansif (p<0,001) ve koroner arter hastalığı (p=0,009) için ilaç kullanımı da PES grubunda yüksek saptandı.Sonuç: Antidepresan ilaç kullanım sıklığının PES grubunda yüksek bulunmasının sebebi PES ve depresyonun her ikisinin patogenezindede ortak olan vasküler hasar ve enflamatuvar proçesler dışında kronik sistemik hastalıkların da yüksek bulunması ile ilgili olabilir.
To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications. Materials and Methods: This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institute database (www.turksat.gov.tr/) as part of an epidemiologic study which specifically aimed to detect the prevalence of PES in the province of Eskişehir. During the examination, a detailed questionnaire was administered to determine physician-diagnosed systemic disease and drug use. Results: Eight of the 2,017 participants in the study were excluded for various reasons (2 with posterior synechiae, 2 with corneal opacity, 1 uncooperative patient, 1 eviscerated patient, 1 with active adenoviral keratoconjunctivitis, and 1 with a history of angle closure). PES was detected in 100 (5%) of the 2,009 patients whose data were analyzed. The percentage of subjects with concurrent antidepressant drug use in the PES and non-PES non-glaucoma groups were 4.1% (n=3) and 1.1% (n=21), respectively. The difference between the two groups was statistically significant (p=0.024). In addition, the use of medications for hypertension (p<0.001) and coronary artery disease (p=0.009) was also higher in the PES group. Conclusion: The higher prevalence of antidepressant drug use in patients with PES may be related to the processes of vascular damage and inflammation common to the pathogenesis of both PES and depression, as well as the high rate of chronic systemic comorbidities in these patients.
To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications. Materials and Methods: This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institute database (www.turksat.gov.tr/) as part of an epidemiologic study which specifically aimed to detect the prevalence of PES in the province of Eskişehir. During the examination, a detailed questionnaire was administered to determine physician-diagnosed systemic disease and drug use. Results: Eight of the 2,017 participants in the study were excluded for various reasons (2 with posterior synechiae, 2 with corneal opacity, 1 uncooperative patient, 1 eviscerated patient, 1 with active adenoviral keratoconjunctivitis, and 1 with a history of angle closure). PES was detected in 100 (5%) of the 2,009 patients whose data were analyzed. The percentage of subjects with concurrent antidepressant drug use in the PES and non-PES non-glaucoma groups were 4.1% (n=3) and 1.1% (n=21), respectively. The difference between the two groups was statistically significant (p=0.024). In addition, the use of medications for hypertension (p<0.001) and coronary artery disease (p=0.009) was also higher in the PES group. Conclusion: The higher prevalence of antidepressant drug use in patients with PES may be related to the processes of vascular damage and inflammation common to the pathogenesis of both PES and depression, as well as the high rate of chronic systemic comorbidities in these patients.
Açıklama
Anahtar Kelimeler
Psödoeksfoliasyon, Depresyon, Antidepresan İlaç, Pseudoexfoliation, Depression, Antidepressant Drug
Kaynak
Türk Oftalmoloji Dergisi (Turkish Journal of Ophthalmology)
WoS Q Değeri
Scopus Q Değeri
Cilt
49
Sayı
1
