Seven coordinated cobalt(II) complexes with 2,6-diacetylpyridine bis(4-acylhydrazone) ligands: Synthesis, characterization, DNA-binding and nuclease activity

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dc.authoridOzcelik, Nefise -- 0000-0002-6972-1071; Gokce, Cansu -- 0000-0002-6834-4841
dc.contributor.authorGökçe, Cansu
dc.contributor.authorDilek, Nefise
dc.contributor.authorGup, Ramazan
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:14Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:14Z
dc.date.issued2015
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractA new series of pentadentate 2,6-diacetylpyridine bis(4-acylhydrazone)s (H2L1 and H2L2) based seven-coordinated cobalt(II) complexes, [Co(L-n)X-2] (n = 1 and X = DMF for (1); n = 2 and X = H2O for (2)); [Co(H2Ln)Y-2] (n = 1 or 2; Y = N-3 or NCS ), has been synthesized and characterized by using spectroscopic techniques. Single crystal X-ray study of [Co(L-1)(DMF)(2)] (1) complex exhibits pentagonal-bipyramidal coordination geometry where the pentadentate N3O2 ligand in the equatorial plane of the bipyramid and two dimethylformamide molecules in the axial area. Interaction of the cobalt(II) complexes with CT DNA has been investigated by absorption titration method and viscosity measurements which reveal that the cobalt(II) complexes could bind with CT DNA through intercalation. Cleavage activity of the complexes (1) and (2) with pBR 322 plasmid DNA was evaluated by agarose gel electrophoresis demonstrating that the ability of the complexes to cleave the pBR 322 plasmid DNA via oxidative pathway, possibly due to the involvement of a diffusible hydroxyl radical mechanism in presence and absence of an oxidative agent. The nuclease activity of the Co(II) complexes has strong dependence on the concentration of complex and reaction time, both in presence and absence of hydrogen peroxide.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [TBAG-112T315]
dc.description.sponsorshipThis work was funded by the Scientific and Technological Research Council of Turkey (TUBITAK, TBAG-112T315).
dc.identifier.doi10.1016/j.ica.2015.03.040
dc.identifier.endpage220en_US
dc.identifier.issn0020-1693
dc.identifier.issn1873-3255
dc.identifier.scopusqualityQ2
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2015.03.040
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5819
dc.identifier.volume432en_US
dc.identifier.wosWOS:000355127300028
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofInorganica Chimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subject2,6-Diacetylpyridine
dc.subjectAcylhydrazone
dc.subjectCobalt(II) Complex
dc.subjectDNA Binding
dc.subjectNuclease Activity
dc.titleSeven coordinated cobalt(II) complexes with 2,6-diacetylpyridine bis(4-acylhydrazone) ligands: Synthesis, characterization, DNA-binding and nuclease activity
dc.typeArticle

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