Effects of beta-1,3-D glucan on systemic bortezomib treated rat pancreas
Yükleniyor...
Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ondokuz Mayıs Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bortezomib, selective inhibitor of the 26S proteasome, is used for treatment of some types of cancer and immunosuppressive therapies. B-1,3(D)-glucan, a synthetic antioxidant is used complementary medical treatment for human. This study was conducted to investigate the effects of the antioxidant Beta-1,3-D glucan on rat pancreas treated with systemic bortezomib. In the study, 36 Sprague-Dawley adult male rats were divided into four groups: control (C), bortezomib (BZ), ?-1, 3-D-glucan (BD) and bortezomib + ?-1,3- (D) –glucan (BZ+BD). Each group was divided into two subgroups (48 or 72 hours), depending on the time of scarification. After experiments, immunohistochemical, stereological and histopathological changes in all rat pancreatic tissues were examined. It was determined increased degenerative, vacuolated serous acini cells and inflammatory cell infiltrations in the groups of BZ and BZ+BG. In immunohistochemical analysis, densities of insulin positive cells were decreased in the groups of BZ and BZ+BG. Furthermore, in stereological mean volume of serous acinus analysis, significantly increases were detected in the groups of BZ and BZ+BG (p<0.05). BZ treatment had the detrimental effects on pancreas tissues. Also, administration of BG was insufficient to prevent injury induced by BZ treatment in the pancreas tissues.
Açıklama
Anahtar Kelimeler
Beta Glucan, Bortezomib, Insulin, Oxidative Stress, Pancreas
Kaynak
Journal of Experimental and Clinical Medicine (Turkey)
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
39
Sayı
3
