4-Methylmorpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, andCoMFAstudy
| dc.authorid | 0000-0002-4257-434X | |
| dc.contributor.author | Pesyan, Nader Noroozi | |
| dc.contributor.author | Rashidnejad, Hamid | |
| dc.contributor.author | Esmaeili, Mohammad Ali | |
| dc.contributor.author | Safari, Elnaz | |
| dc.contributor.author | Tunç, Tuncay | |
| dc.contributor.author | Alilou, Mostafa | |
| dc.contributor.author | Safavi-Sohi, Reihaneh | |
| dc.contributor.author | Şahin, Ertan | |
| dc.date.accessioned | 2021-06-29T07:30:56Z | |
| dc.date.available | 2021-06-29T07:30:56Z | |
| dc.date.issued | 2020 | |
| dc.department | Eğitim Fakültesi | |
| dc.description | *Tunç, Tuncay ( Aksaray, Yazar ) | |
| dc.description.abstract | The reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecularH-bonds. X-ray Crystallography, FT-IR, and(1)H and(13)C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained. | |
| dc.identifier.doi | 10.1002/jccs.202000057 | |
| dc.identifier.endpage | 1695 | en_US |
| dc.identifier.issue | 9 | en_US |
| dc.identifier.startpage | 1679 | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.1002/jccs.202000057 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/8214 | |
| dc.identifier.volume | 67 | en_US |
| dc.identifier.wos | WOS:000565364100001 | |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.language.iso | en | |
| dc.publisher | Wiley-VCH | |
| dc.relation.ispartof | Journal of the Chinese Chemical Society | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | 4-methyl Morpholine | |
| dc.subject | Anticancer Effect | |
| dc.subject | Barbituric Acid | |
| dc.subject | CoMFA Study | |
| dc.subject | Eight-membered IntramolecularH-bond | |
| dc.subject | Negative Charge-assistedH-bonds | |
| dc.subject | Resonance-assistedH-bonds | |
| dc.title | 4-Methylmorpholinium bis-(thio)barbiturates: Synthesis, structure, anticancer evaluation, andCoMFAstudy | |
| dc.type | Article |
