What is the restorative effect of VEGF inhibitor bevacuzimab against subarachnoid hemorrhage in an experimental model

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dc.authorid0000-0002-5791-0094
dc.authorid0000-0002-4813-0854
dc.authorid0000-0001-9861-274X
dc.authorid0000-0003-1738-5923
dc.authorid0000-0003-1738-5923
dc.authorid0000-0001-9924-7051
dc.authorid0000-0002-7759-7568
dc.authorid0000-0001-8541-8251
dc.authorid0000-0001-6413-7362
dc.authorid0000-0003-0628-0173
dc.contributor.authorDemirci, Adnan Yalçın
dc.contributor.authorGüvenç, Yahya
dc.contributor.authorÖzeren, Ersin
dc.contributor.authorAkyol, Çetin
dc.contributor.authorBayram, Pınar
dc.contributor.authorBillur, Deniz
dc.contributor.authorAydın, Sevim
dc.contributor.authorSeçkin, Hakan
dc.contributor.authorYiğitkanlı, Kazım
dc.date.accessioned2021-12-13T09:53:51Z
dc.date.available2021-12-13T09:53:51Z
dc.date.issued2021
dc.departmentTıp Fakültesi
dc.description.abstractBackground/aim: This study investigated the effect of vascular endothelial growth factor (VEGF) inhibitor bevacuzimab (BVZ) on the rabbit basilar artery using an experimental subarachnoid hemorrhage (SAH) model. Materials and methods: Eighteen adult male New-Zealand white rabbits were randomly divided into three groups: a control group (n = 6), SAH group (n = 6), and SAH+BVZ group (n = 6). Experimental SAH was created by injecting autologous arterial blood into the cisterna magna. In the treatment group, the subjects were administered a daily dose of 10 mg/kg, intravenous BVZ for 2 days after the SAH. Basilar artery diameters were measured with magnetic resonance angiography (MRA) 72 h after the SAH in all groups. After 72 h, whole brains, including the upper cervical region, were obtained from all the animals after perfusion and fixation of the animal. The wall thickness, luminal area, and the apoptosis at the basilar arteries were evaluated in all groups. Results: BVZ significantly prevented SAH-induced vasospasm confirmed in vivo with MRA imaging with additional suppression of apoptosis on basilar artery wall. Conclusion: VEGF inhibition with BVZ has shown to have a vasospasm and apoptosis attenuating effect on basilar artery in a SAH model.
dc.identifier.doi10.3906/sag-2001-230
dc.identifier.endpage2704en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.pmid33356024
dc.identifier.startpage2698en_US
dc.identifier.urihttps:/dx.doi.org/10.3906/sag-2001-230
dc.identifier.urihttps://hdl.handle.net/20.500.12451/8933
dc.identifier.volume51en_US
dc.identifier.wosWOS:000711339600055
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherTÜBİTAK
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectBevacizumab
dc.subjectSubarachnoid Hemorrhage
dc.subjectVasoconstriction
dc.subjectVascular Endothelial Growth Factors
dc.titleWhat is the restorative effect of VEGF inhibitor bevacuzimab against subarachnoid hemorrhage in an experimental model
dc.typeArticle

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