Synthesis of Bis-spiro Cyclopropanes Based on Meldrum's Acid by Milling

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Küçük Resim

Tarih

2015

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Wiley-Blackwell

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Reaction of 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid) with various solid aldehydes in the presence of cyanogen bromide and solid sodium ethoxide (EtONa) leads to the selective and efficient formation of bis-spiro cyclopropanes based on Meldrum's acid at the range of 0 degrees C to room temperature. The products were obtained in good to excellent yields. Structure elucidation is carried out by H-1 NMR, C-13 NMR, FT-IR spectroscopy, mass analyses and X-ray crystallography techniques. A possible mechanism for the formation of products is also discussed under solvent-free condition.

Açıklama

Anahtar Kelimeler

Meldrum's acid, Aldehyde, Cyanogen Bromide, Bis-spiro Cyclopropanes, Milling, Solid Sodium Ethoxide

Kaynak

Journal of the Chinese Chemical Society

WoS Q Değeri

N/A

Scopus Q Değeri

Cilt

62

Sayı

3

Künye