Determination of secondary metabolites of Cydonia oblonga (Quince) by LC-MS/MS method together with evaluation of its antioxidant and cholinergic potentials

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dc.authorid0000-0002-3086-8156
dc.authorid0000-0002-0820-912X
dc.authorid0000-0001-6213-7297
dc.authorid0000-0002-4677-8104
dc.authorid0000-0002-1026-972X
dc.authorid0000-0001-5993-1668
dc.contributor.authorDikici, Emrah
dc.contributor.authorAltın, Sevgi
dc.contributor.authorAlp, Cemalettin
dc.contributor.authorIşık, Mesut
dc.contributor.authorKöksal, Ekrem
dc.contributor.authorGülçin, İlhami
dc.date.accessioned2025-02-25T13:37:58Z
dc.date.available2025-02-25T13:37:58Z
dc.date.issued2024
dc.departmentRektörlük
dc.description.abstractIn this study, quantification of secondary metabolites of Cydonia oblonga (Quince) leaves by LC-MS/MS and antioxidant, cholinergic and ?-Glycosidase activities were reported. LC-MS/MS analyses of the studied extract showed that the highest phenolic constituents of species were catechin (2024.9 ± 80.9 ?g/L), vanillic acid (1121.8 ± 39.3 ?g/L) and fumaric acid (486.7 ± 16.5 ?g/L). The ethanol extract of quince leaves inhibited the ?-glycosidase enzyme with an IC50: 0.6 ?g/mL value. In order to determine the anti-Alzheimer activity of the plant extract, inhibition studies were carried out on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. The IC50 values of the plant extract were found to be 1.3 ?g/mL for AChE and 1.5 ?g/mL for BChE. In addition, free radical scavenging and metal reduction tests were performed to determine the antioxidant activity of the plant and the results were compared with Trolox. It was understood that the antioxidant potential of the plant was lower than Trolox. The results from biological abilities, molecular docking of catechin hydrate as abundant phenolic compounds in quince leaves extract to be an inhibitor candidate for AChE, BChE and ?-glycosidase.
dc.identifier.doi10.25135/jcm.120.2411.3380
dc.identifier.endpage164en_US
dc.identifier.issn1307-6183
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage146en_US
dc.identifier.urihttps://dx.doi.org/10.25135/jcm.120.2411.3380
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12965
dc.identifier.volume18en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherACG Publications
dc.relation.ispartofJournal of Chemical Metrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer’s Disease
dc.subjectAntioxidant
dc.subjectEnzyme Inhibition
dc.subjectMolecular Docking
dc.subjectPolyphenol Content
dc.subjectQuince
dc.titleDetermination of secondary metabolites of Cydonia oblonga (Quince) by LC-MS/MS method together with evaluation of its antioxidant and cholinergic potentials
dc.typeArticle

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