Sponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications

Basit Öğe Kaydı
dc.contributor.authorKaya, Murat
dc.contributor.authorBilican, İsmail
dc.contributor.authorMujtaba, Muhammad
dc.contributor.authorSargın, İdris
dc.contributor.authorHaskoylu, Merve Erginer
dc.contributor.authorÖner, Ebru Toksoy
dc.contributor.authorZheng, Kai
dc.contributor.authorBoccaccini, Aldo R.
dc.contributor.authorCansaran Duman, Demet
dc.contributor.authorÖnses, M. Serdar
dc.contributor.authorTorun, ilker
dc.contributor.authorAkyüz, Lalehan
dc.contributor.authorElbüken, Çağlar
dc.date.accessioned2021-04-28T06:33:58Z
dc.date.available2021-04-28T06:33:58Z
dc.date.issued2021
dc.departmentRektörlük
dc.description*Bilican, Ismail ( Aksaray, Yazar )
dc.description.abstractPorous, bioactive microspheres have always been a dream material to biomedical scientists for bone regeneration and drug delivery applications due to their interconnectivity, unique pore geometry, encapsulation ability and porosity spanning macroscopic, microscopic and nanoscopic length scales. Extensive efforts have been made to produce such materials synthetically at a great cost of money, time and labor. Herein, naturally-assembled multifunctional, open-channeled and hollow bioactive micro silica spheres (diameter 209.4 +/- 38.5 mu m) were discovered in a marine sponge (Geodia macandrewii), by peeling the outer surface of the sterrasters using hydrogen fluoride. The obtained micro silica spheres exhibited valuable characteristics such as homogeneously distributed pores, a cavity in the center of the sphere, and channels (approx. 3000) opening from each pore into the central cavity. Simulated body fluid analysis demonstrated the bioactivity of the micro silica spheres; whereas, no bioactivity was recorded for the original untreated sterrasters. The non-cytotoxicity and osteogenic ability of the isolated microspheres were confirmed through osteoblast cell culture. Finally, these silica based porous microspheres were tested for controlled drug release capacity. The spheres showed excellent loading and release abilities for an anti-cancer drug, carboplatin, in simulated solutions and in human cancer cell culture, HeLa, through a real time cell analyzer system. The drug loading capacity of the porous beads was determined as 10.59%. Considering the unique biological and physicochemical properties, these novel bioactive silica spheres, which we name as giant macroporous silica (GMS), are promising materials for a range of applications including bone tissue engineering and drug delivery.
dc.identifier.doi10.1016/j.cej.2020.126667
dc.identifier.endpage-en_US
dc.identifier.issue-en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage-en_US
dc.identifier.urihttps:/dx.doi.org/10.1016/j.cej.2020.126667
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7907
dc.identifier.volume407en_US
dc.identifier.wosWOS:000607599400005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofChemical Engineering Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Başka Kurum Yazarı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiosilica
dc.subjectPorous Beads
dc.subjectMacroporous Silica
dc.subjectBone Tissue
dc.subjectDrug Release
dc.subjectPorifera
dc.subjectGeodia
dc.subjectSterrasters
dc.titleSponge-derived natural bioactive glass microspheres with self-assembled surface channel arrays opening into a hollow core for bone tissue and controlled drug release applications
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
kaya-murat-2021.pdf
Boyut:
11.9 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu