The Protective Role of Syringic Acid on Ovarian Injury Created by Ischemia Reperfusion

dc.authorid0000-0001-8593-5726
dc.authorid0000-0002-0095-0917
dc.authorid0000-0003-2424-2269
dc.authorid0000-0001-8588-1035
dc.authorid0000-0001-9585-3169
dc.authorid0000-0002-7618-5043
dc.authorid0000-0003-3780-4021
dc.contributor.authorTopdağı Yılmaz, Emsal Pınar
dc.contributor.authorTanyeli, Ayhan
dc.contributor.authorEraslan, Ersen
dc.contributor.authorGüler, Mustafa Can
dc.contributor.authorEkinci Akdemir, Fazile Nur
dc.contributor.authorGüzel Erdoğan, Derya
dc.contributor.authorTaşpınar, Filiz
dc.date.accessioned2024-06-28T07:31:03Z
dc.date.available2024-06-28T07:31:03Z
dc.date.issued2024
dc.departmentTıp Fakültesi
dc.description.abstractSyringic acid (SA), a natural phenolic substance, possesses anti-inflammatory and antioxidant properties. We investigated the likely preventive effects of SA on organ damage to the reproductive system caused by bilateral ovarian ischemia -reperfusion (I/R). Materials and Methods: 32 female Sprague-Dawley rats in total were used; they were split into four groups: a sham group for co ntrol (group I), I/R group (group II), I/R group given 10 mg/kg SA (group III), and an I/R group given 50 mg/kg SA (group IV). Grou p I underwent only an abdominal incision without I/R. In groups II, III, and IV, I/R procedures were conducted for 3 hours. S A was given intraperitoneally to groups III and IV for 30 minutes before reperfusion at 10 mg/kg and 50 mg/kg, respectively. The ovarian tissues were surgically removed for analysis. Results: TNF-?, MDA, IL-1?, MPO, TOS and OSI levels in group II were found to be significantly higher than in group I. Additionally, a decrease was detected in TAS and SOD values in group II. In contrast, SA administration led to significant increases in the level of antioxidant enzymes in both groups III and IV. Also, in the SA-given groups, significant decreases were detected in OSI and TOS levels, along with a decrease in MPO, MDA, TNF-?, and IL-1? levels. Conclusion: It has been demonstrated that SA has a protective effect against organ damage caused by bilateral ovarian I/R in the reproductive system. This is the first study to show that SA can reduce ovarian damage due to I/R injury.
dc.identifier.doi10.5505/vmj.2024.93609
dc.identifier.endpage132en_US
dc.identifier.issn1300-2694
dc.identifier.issn2587-0351
dc.identifier.issue2en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps:/dx.doi.org/10.5505/vmj.2024.93609
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11981
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherVan Yüzüncü Yıl Üniversitesi Tıp Fakültesi
dc.relation.ispartofVan Tıp Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIschemia Reperfusion
dc.subjectSyringic Acid
dc.subjectOvary
dc.subjectOxidative Stress
dc.titleThe Protective Role of Syringic Acid on Ovarian Injury Created by Ischemia Reperfusion
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Yükleniyor...
Küçük Resim
İsim:
topdagi-emsal pinar-2024.pdf
Boyut:
484.98 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama: